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    pdzd-8 PDZ Domain containing [ Caenorhabditis elegans ]

    Gene ID: 177716, updated on 2-Nov-2024

    Summary

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    Official Symbol
    pdzd-8
    Official Full Name
    PDZ Domain containing
    Primary source
    WormBase:WBGene00008274
    Locus tag
    CELE_C53B4.4
    See related
    AllianceGenome:WB:WBGene00008274
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lipid binding activity and metal ion binding activity. Predicted to be involved in mitochondrial calcium ion homeostasis and mitochondrion-endoplasmic reticulum membrane tethering. Predicted to be located in mitochondrion. Predicted to be active in mitochondria-associated endoplasmic reticulum membrane contact site. Orthologous to human PDZD8 (PDZ domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See pdzd-8 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    18
    Sequence:
    Chromosome: IV; NC_003282.8 (8975526..8984579)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene UAA transporter Neighboring gene GDP-mannose 4,6 dehydratase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PDZD-8 and TEX-2 regulate endosomal PI(4,5)P(2) homeostasis via lipid transport to promote embryogenesis in C. elegans. Jeyasimman D, et al. Nat Commun, 2021 Oct 18. PMID 34663803, Free PMC Article
    2. A specificity map for the PDZ domain family. Tonikian R, et al. PLoS Biol, 2008 Sep 30. PMID 18828675, Free PMC Article
    3. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Shen X, et al. Cell Calcium, 2008 May. PMID 17854888
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PDZD-8 and TEX-2 regulate endosomal PI(4,5)P2 homeostasis via lipid transport to promote embryogenesis in C. elegans.
      Title: PDZD-8 and TEX-2 regulate endosomal PI(4,5)P(2) homeostasis via lipid transport to promote embryogenesis in C. elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrion-endoplasmic reticulum membrane tethering IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondria-associated endoplasmic reticulum membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondria-associated endoplasmic reticulum membrane contact site IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PDZ Domain containing
    NP_001023093.1
    • Confirmed by transcript evidence
    NP_001122764.2
    • Confirmed by transcript evidence
    NP_001294056.1
    • Confirmed by transcript evidence
    NP_001294057.1
    • Confirmed by transcript evidence
    NP_001360495.1
    • Confirmed by transcript evidence
    NP_001360496.1
    • Confirmed by transcript evidence
    NP_001360497.1
    • Confirmed by transcript evidence
    NP_001360498.1
    • Confirmed by transcript evidence
    NP_001360499.1
    • Confirmed by transcript evidence
    NP_501558.2
    • Confirmed by transcript evidence
    NP_501559.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      8975526..8984579
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129292.5 → NP_001122764.2  PDZ Domain containing [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122764.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A5JYS5
      Conserved Domains (2) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:995 → 1040
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    2. NM_001372894.3 → NP_001360498.1  PDZ Domain containing [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WTK6
      Conserved Domains (3) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:997 → 1042
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      TIGR02037
      Location:347 → 492
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    3. NM_001372897.2 → NP_001360496.1  PDZ Domain containing [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WWK3
      Conserved Domains (3) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:997 → 1042
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      TIGR02037
      Location:347 → 492
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    4. NM_001372898.2 → NP_001360497.1  PDZ Domain containing [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WXK7
      Conserved Domains (3) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:995 → 1040
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      TIGR02037
      Location:347 → 492
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    5. NM_001372896.2 → NP_001360495.1  PDZ Domain containing [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WVD0
      Conserved Domains (3) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:997 → 1042
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      TIGR02037
      Location:347 → 492
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    6. NM_069158.5 → NP_501559.2  PDZ Domain containing [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501559.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JM28
      Conserved Domains (2) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:995 → 1040
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    7. NM_069157.5 → NP_501558.2  PDZ Domain containing [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501558.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18798
      Conserved Domains (2) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:997 → 1042
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    8. NM_001372895.3 → NP_001360499.1  PDZ Domain containing [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WX00
      Conserved Domains (3) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:995 → 1040
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      TIGR02037
      Location:347 → 492
      degP_htrA_DO; periplasmic serine protease, Do/DeqQ family

    9. NM_001027922.6 → NP_001023093.1  PDZ Domain containing [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001023093.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q5WRP6
      Conserved Domains (2) summary
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd00029
      Location:936 → 981
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    10. NM_001307128.3 → NP_001294057.1  PDZ Domain containing [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294057.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LXA1
      Conserved Domains (3) summary
      smart00109
      Location:938 → 983
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd21674
      Location:68 → 258
      SMP_PDZD8; synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in PDZ domain-containing protein 8 (PDZD8) and similar proteins

    11. NM_001307127.3 → NP_001294056.1  PDZ Domain containing [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X5LQ14
      Conserved Domains (3) summary
      smart00109
      Location:936 → 981
      C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
      smart00228
      Location:354 → 414
      PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
      cd21674
      Location:68 → 258
      SMP_PDZD8; synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in PDZ domain-containing protein 8 (PDZD8) and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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