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    rml-1 UTP--glucose-1-phosphate uridylyltransferase [ Caenorhabditis elegans ]

    Gene ID: 176814, updated on 14-Nov-2024

    Summary

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    Official Symbol
    rml-1
    Official Full Name
    UTP--glucose-1-phosphate uridylyltransferase
    Primary source
    WormBase:WBGene00010665
    Locus tag
    CELE_K08E3.5
    See related
    AllianceGenome:WB:WBGene00010665
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables UTP:glucose-1-phosphate uridylyltransferase activity. Involved in UDP-glucose metabolic process. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in body wall musculature; hypodermis; and intestine. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 83. Orthologous to human UGP2 (UDP-glucose pyrophosphorylase 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See rml-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    10
    Sequence:
    Chromosome: III; NC_003281.10 (13764030..13768092, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene Transducer of Cdc42-dependent actin assembly protein 2 homolog Neighboring gene DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog Neighboring gene Rac GTPase-activating protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase parkin;RBR-type E3 ubiquitin transferase;Ubiquitin-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. Yu Q, et al. Biochem J, 2012 Mar 1. PMID 22132858
    2. Acquired stress resilience through bacteria-to-nematode interdomain horizontal gene transfer. Pandey T, et al. EMBO J, 2023 Dec 11. PMID 37953666, Free PMC Article
    3. Isolation and molecular identification of nematode surface mutants with resistance to bacterial pathogens. O'Rourke D, et al. G3 (Bethesda), 2023 May 2. PMID 36911920, Free PMC Article
    4. A quantitative genome-wide RNAi screen in C. elegans for antifungal innate immunity genes. Zugasti O, et al. BMC Biol, 2016 Apr 29. PMID 27129311, Free PMC Article
    5. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UTP:glucose-1-phosphate uridylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UTP:glucose-1-phosphate uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UTP:glucose-1-phosphate uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-alpha-D-glucose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP-alpha-D-glucose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP-alpha-D-glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in sarcomere HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    UTP--glucose-1-phosphate uridylyltransferase
    NP_001022671.1
    • Confirmed by transcript evidence
    NP_001379213.1
    • Confirmed by transcript evidence
    NP_001379395.1
    • Confirmed by transcript evidence
    NP_499841.1
    • Confirmed by transcript evidence
    NP_499842.1
    • Confirmed by transcript evidence
    NP_499843.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13764030..13768092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067441.4 → NP_499842.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUS5
      Conserved Domains (1) summary
      pfam01704
      Location:73 → 487
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    2. NM_001027500.7 → NP_001022671.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001022671.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q69Z13
      Conserved Domains (1) summary
      pfam01704
      Location:44 → 458
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    3. NM_001392235.1 → NP_001379213.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUS6
      Conserved Domains (1) summary
      pfam01704
      Location:58 → 474
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    4. NM_001392234.1 → NP_001379395.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86D12
      Conserved Domains (1) summary
      pfam01704
      Location:45 → 461
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    5. NM_067440.8 → NP_499841.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499841.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XUS4
      Conserved Domains (1) summary
      pfam01704
      Location:62 → 476
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase

    6. NM_067442.6 → NP_499843.1  UTP--glucose-1-phosphate uridylyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499843.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8WQE5
      Conserved Domains (1) summary
      pfam01704
      Location:73 → 462
      UDPGP; UTP--glucose-1-phosphate uridylyltransferase
    Nucleotide Protein
    Heading Accession and Version

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