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    cnc-2 CaeNaCin (Caenorhabditis bacteriocin) [ Caenorhabditis elegans ]

    Gene ID: 178637, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cnc-2
    Official Full Name
    CaeNaCin (Caenorhabditis bacteriocin)
    Primary source
    WormBase:WBGene00000556
    Locus tag
    CELE_R09B5.3
    See related
    AllianceGenome:WB:WBGene00000556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in defense response to Gram-negative bacterium; defense response to fungus; and innate immune response. Predicted to be located in extracellular space. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cnc-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_003283.11 (1449667..1450183, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CaeNaCin (Caenorhabditis bacteriocin) Neighboring gene CaeNaCin (Caenorhabditis bacteriocin) Neighboring gene Serpentine Receptor, class J;Serpentine receptor class gamma Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Investigation of the Potential Antifungal Properties of CNC-2 in Caenorhabditis elegans. Zehrbach AMD, et al. J Nematol, 2017 Dec. PMID 29353937, Free PMC Article
    2. BMP signaling to pharyngeal muscle in the C. elegans response to a bacterial pathogen regulates anti-microbial peptide expression and pharyngeal pumping. Ciccarelli EJ, et al. Mol Biol Cell, 2024 Apr 1. PMID 38381557, Free PMC Article
    3. C. elegans orphan nuclear receptor NHR-42 represses innate immunity and promotes lipid loss downstream of HLH-30/TFEB. Goswamy D, et al. Front Immunol, 2023. PMID 36860863, Free PMC Article
    4. Functional disruption in epidermal barrier enhances toxicity and accumulation of graphene oxide. Ding X, et al. Ecotoxicol Environ Saf, 2018 Nov 15. PMID 30075448
    5. Identification and Functional Analysis of Cytokine-Like Protein CLEC-47 in Caenorhabditis elegans. Pan W, et al. mBio, 2021 Oct 26. PMID 34634942, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CaeNaCin (Caenorhabditis bacteriocin)
    NP_001300172.1
    • Product from WormBase gene class cnc;
      Partially confirmed by transcript evidence
    NP_503418.1
    • Product from WormBase gene class cnc;
      Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      1449667..1450183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071017.6 → NP_503418.1  CaeNaCin (Caenorhabditis bacteriocin) [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503418.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44611

    2. NM_001313243.2 → NP_001300172.1  CaeNaCin (Caenorhabditis bacteriocin) [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ASA3
    Nucleotide Protein
    Heading Accession and Version

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