cyb-2.1 G2/mitotic-specific cyclin-B [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cyb-2.1
Official Full Name: G2/mitotic-specific cyclin-B
Primary source: WormBase:WBGene00000866
Locus tag: CELE_Y43E12A.1
See related: AllianceGenome:WB:WBGene00000866
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in anterior/posterior axis specification, embryo and oocyte maturation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in germ line. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to several human genes including CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyb-2.1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 4

Sequence:: Chromosome: IV; NC_003282.8 (10985985..10987426)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our results support a model in which CYB-2.1/2/CDK-1 antagonize CUL-2 activity to promote stabilization of PAR-6 levels during polarization of the early C. elegans embryo.
Title: CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y43E12A.1 (e-PCR)
- UniSTS:308176

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in anterior/posterior axis specification, embryo	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell cycle	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle phase transition	IEA Inferred from Electronic Annotation more info
involved_in oocyte maturation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G2/mitotic-specific cyclin-B

NP_502047.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10985985..10987426

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_069646.8 → NP_502047.1 G2/mitotic-specific cyclin-B [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_502047.1

Status: REVIEWED

UniProtKB/TrEMBL

O45926

Conserved Domains (2) summary

COG5024
Location:32 → 300

COG5024; Cyclin [Cell division and chromosome partitioning]

pfam00134
Location:34 → 159

Cyclin_N; Cyclin, N-terminal domain