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    cng-1 Cyclic nucleotide-binding domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180004, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cng-1
    Official Full Name
    Cyclic nucleotide-binding domain-containing protein
    Primary source
    WormBase:WBGene00000562
    Locus tag
    CELE_F14H8.6
    See related
    AllianceGenome:WB:WBGene00000562
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Involved in several processes, including negative regulation of cGMP-mediated signaling; sensory perception of chemical stimulus; and sensory processing. Located in neuronal cell body. Is expressed in amphid neurons and head neurons. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cng-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (15025731..15031473, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Mediator of RNA polymerase II transcription subunit 7 Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The cyclic nucleotide gated channel subunit CNG-1 instructs behavioral outputs in Caenorhabditis elegans by coincidence detection of nutritional status and olfactory input. He C, et al. Neurosci Lett, 2016 Oct 6. PMID 27561605
    2. Mutations in the guanylate cyclase gcy-28 neuronally dissociate naïve attraction and memory retrieval. Li N, et al. Eur J Neurosci, 2018 Dec. PMID 30362188
    3. Identification and characterization of a putative cyclic nucleotide-gated channel, CNG-1, in C. elegans. Cho SW, et al. Mol Cells, 2005 Feb 28. PMID 15750353
    4. A new putative cyclic nucleotide-gated channel gene, cng-3, is critical for thermotolerance in Caenorhabditis elegans. Cho SW, et al. Biochem Biophys Res Commun, 2004 Dec 10. PMID 15530424
    5. Cell- and subunit-specific mechanisms of CNG channel ciliary trafficking and localization in C. elegans. Wojtyniak M, et al. J Cell Sci, 2013 Oct 1. PMID 23886944, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We found that the cyclic nucleotide gated channel subunit CNG-1 is required to promote cross adaptation responses between distinct olfactory cues. We also reveal that CNG-1 integrates food related cues for exploratory motor output, revealing that CNG-1 functions in multiple capacities to link nutritional information with behavioral output.
      Title: The cyclic nucleotide gated channel subunit CNG-1 instructs behavioral outputs in Caenorhabditis elegans by coincidence detection of nutritional status and olfactory input.
    2. molecular characterization of gene F14H8.6, designated cng-1, which encodes a putatitve cyclic nucleotide-gated channel alpha subunit
      Title: Identification and characterization of a putative cyclic nucleotide-gated channel, CNG-1, in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cGMP-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cGMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of chemical stimulus IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory perception of chemical stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sensory processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Cyclic nucleotide-binding domain-containing protein
    NP_001122918.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      15025731..15031473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129446.5 → NP_001122918.1  Cyclic nucleotide-binding domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122918.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8WI01
      Conserved Domains (3) summary
      PLN03192
      Location:153 → 568
      PLN03192; Voltage-dependent potassium channel; Provisional
      cd00038
      Location:446 → 563
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam16526
      Location:562 → 633
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    RNA

    1. NR_070019.1 RNA Sequence

      Status: REVIEWED

    2. NR_070020.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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