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    scpl-4 Mitochondrial import inner membrane translocase subunit TIM50 [ Caenorhabditis elegans ]

    Gene ID: 179481, updated on 9-Dec-2024

    Summary

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    Official Symbol
    scpl-4
    Official Full Name
    Mitochondrial import inner membrane translocase subunit TIM50
    Primary source
    WormBase:WBGene00011897
    Locus tag
    CELE_T21C9.12
    See related
    AllianceGenome:WB:WBGene00011897
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in protein import into mitochondrial matrix. Predicted to be located in mitochondrial inner membrane. Predicted to be part of TIM23 mitochondrial import inner membrane translocase complex. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 9. Orthologous to human TIMM50 (translocase of inner mitochondrial membrane 50). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See scpl-4 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    8
    Sequence:
    Chromosome: V; NC_003283.11 (10599104..10602146)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF4149 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene glutaminyl-peptide cyclotransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Psr1p/Psr2p, two plasma membrane phosphatases with an essential DXDX(T/V) motif required for sodium stress response in yeast. Siniossoglou S, et al. J Biol Chem, 2000 Jun 23. PMID 10777497
    2. A novel protein phosphatase is a binding partner for the protein kinase domains of UNC-89 (Obscurin) in Caenorhabditis elegans. Qadota H, et al. Mol Biol Cell, 2008 Jun. PMID 18337465, Free PMC Article
    3. Unbiased identification of substrates of protein tyrosine phosphatase ptp-3 in C. elegans. Mitchell CJ, et al. Mol Oncol, 2016 Jun. PMID 27067626, Free PMC Article
    4. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans. Emerson FJ, et al. Nat Commun, 2024 Mar 14. PMID 38485937, Free PMC Article
    5. The RNA-binding protein repertoire of Arabidopsis thaliana. Marondedze C, et al. Sci Rep, 2016 Jul 11. PMID 27405932, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mitochondrial import inner membrane translocase subunit TIM50
    NP_001360575.1
    • Confirmed by transcript evidence
    NP_505722.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10599104..10602146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373099.3 → NP_001360575.1  Mitochondrial import inner membrane translocase subunit TIM50 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A486WU22
      Conserved Domains (1) summary
      pfam03031
      Location:247 → 395
      NIF; NLI interacting factor-like phosphatase

    2. NM_073321.7 → NP_505722.1  Mitochondrial import inner membrane translocase subunit TIM50 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q22647
      Conserved Domains (1) summary
      pfam03031
      Location:248 → 396
      NIF; NLI interacting factor-like phosphatase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q22647.1

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