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    tmem-135 Transmembrane protein 135 homolog [ Caenorhabditis elegans ]

    Gene ID: 180740, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tmem-135
    Official Full Name
    Transmembrane protein 135 homolog
    Primary source
    WormBase:WBGene00019345
    Locus tag
    CELE_K02G10.3
    See related
    AllianceGenome:WB:WBGene00019345
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Acts upstream of or within several processes, including determination of adult lifespan; positive regulation of lipid storage; and positive regulation of mitochondrial membrane potential. Located in cytoplasm and lipid droplet. Is expressed in epithelial system; intestine; and pharynx. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tmem-135 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    10
    Sequence:
    Chromosome: X; NC_003284.9 (4673706..4677350)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene Major facilitator superfamily domain-containing protein 12 Neighboring gene SPLDEEDFAPESPLQ-amide Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. Exil VJ, et al. PLoS One, 2010 Dec 3. PMID 21151927, Free PMC Article
    2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM135 integrates biological processes involving fat metabolism and energy expenditure in both the worm (invertebrates) and in mammalian organisms
      Title: Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of adult lifespan IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of lipid storage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mitochondrial membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to food IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transmembrane protein 135 homolog
    NP_508800.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4673706..4677350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076399.10 → NP_508800.2  Transmembrane protein 135 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508800.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95QD1
      Conserved Domains (1) summary
      pfam15982
      Location:20 → 149
      TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95QD1.2

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