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    Akap200 A kinase anchor protein 200 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34170, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Akap200provided by FlyBase
    Official Full Name
    A kinase anchor protein 200provided by FlyBase
    Primary source
    FLYBASE:FBgn0027932
    Locus tag
    Dmel_CG13388
    See related
    AllianceGenome:FB:FBgn0027932
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Akap 200; akap200; AKAP200; anon-WO0118547.134; anon-WO0118547.213; BcDNA:LP02734; CG13388; DAKAP200; Dmel\CG13388; dpo; EP(2)2254; MESR2
    Summary
    Enables Notch binding activity; actin filament binding activity; and protein kinase A regulatory subunit binding activity. Involved in several processes, including positive regulation of Notch signaling pathway; positive regulation of protein localization to membrane; and response to ethanol. Located in cytoskeleton; cytosol; and plasma membrane. Is expressed in several structures, including adult head; cell body glial cell; dorsal ectoderm anlage; epithelium; and head epidermis primordium. Used to study alcohol use disorder. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Akap200 in Genome Data Viewer
    Location:
    29C3-29C4; 2-32 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8415690..8431297)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8415690..8431297)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene N-acetyl-alpha-glucosaminidase Neighboring gene uncharacterized protein Neighboring gene gurken Neighboring gene D12 Neighboring gene Chromatin accessibility complex 14kD protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C kinase substrate is due to nonspecific electrostatic interactions. Wang J, et al. J Biol Chem, 2002 Sep 13. PMID 12097325
    2. Characterization of the targeting, binding, and phosphorylation site domains of an A kinase anchor protein and a myristoylated alanine-rich C kinase substrate-like analog that are encoded by a single gene. Rossi EA, et al. J Biol Chem, 1999 Sep 17. PMID 10480937
    3. PARP1 is a versatile factor in the regulation of mRNA stability and decay. Matveeva EA, et al. Sci Rep, 2019 Mar 6. PMID 30842529, Free PMC Article
    4. Oxidative stress-induced changes in the transcriptomic profile of extracellular vesicles. Dellar ER, et al. J Extracell Biol, 2024 Apr. PMID 38938847, Free PMC Article
    5. Generation of a novel A kinase anchor protein and a myristoylated alanine-rich C kinase substrate-like analog from a single gene. Li Z, et al. J Biol Chem, 1999 Sep 17. PMID 10480936

    See all (112) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ethanol causes a structural remodeling of the actin cytoskeleton and perineurial membrane topology in an Akap200-dependent manner, without disrupting classical barrier functions.
      Title: Perineurial Barrier Glia Physically Respond to Alcohol in an Akap200-Dependent Manner to Promote Tolerance.
    2. AKAP200 is a novel tissue specific posttranslational regulator of Notch, maintaining high Notch protein levels and thus promoting Notch signaling.
      Title: AKAP200 promotes Notch stability by protecting it from Cbl/lysosome-mediated degradation in Drosophila melanogaster.
    3. Overexpression of Akap200 not only suppresses the phenotype caused by Dv-cbl expression, but also the severe disruption to eye development caused by the combined expression of Dv-cbl and activated Ras
      Title: Akap200 suppresses the effects of Dv-cbl expression in the Drosophila eye.
    4. Overexpression of Akap200 resulted in fusion of antennal glomeruli, while its loss resulted in misshapen and ectopic glomeruli.
      Title: Misexpression screen for genes altering the olfactory map in Drosophila.
    5. Akap200 is required for protein kinase A regulatory subunit localization and morphology of actin structures during oogenesis in Drosophila
      Title: An A-kinase anchoring protein is required for protein kinase A regulatory subunit localization and morphology of actin structures during oogenesis in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables Notch binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase A regulatory subunit binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein localization to membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    A kinase anchor protein 200
    Names
    A kinase anchor protein
    Akap200-PA
    Akap200-PB
    Akap200-PC
    Akap200-PD
    Akap200-PE
    Akap200-PF
    Akap200-PG
    CG13388-PA
    CG13388-PB
    CG13388-PC
    CG13388-PD
    CG13388-PE
    CG13388-PF
    CG13388-PG

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8415690..8431297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_175984.1 → NP_787998.1  A kinase anchor protein 200, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787998.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BM5
      Related
      FBpp0079282, FBtr0079667
      Conserved Domains (1) summary
      PRK10811
      Location:492 → 671
      rne; ribonuclease E; Reviewed

    2. NM_001298823.1 → NP_001285752.1  A kinase anchor protein 200, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285752.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U7E6
      Conserved Domains (1) summary
      PRK10811
      Location:144 → 319
      rne; ribonuclease E; Reviewed

    3. NM_001298822.1 → NP_001285751.1  A kinase anchor protein 200, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IPF5, Q9U7E7, Q9VLL3
      Conserved Domains (2) summary
      PRK10811
      Location:408 → 587
      rne; ribonuclease E; Reviewed
      PRK12270
      Location:187 → 275
      kgd; alpha-ketoglutarate decarboxylase; Reviewed

    4. NM_058112.4 → NP_477460.1  A kinase anchor protein 200, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IPF5, Q9U7E7, Q9VLL3
      Related
      FBpp0079279
      Conserved Domains (2) summary
      PRK10811
      Location:408 → 587
      rne; ribonuclease E; Reviewed
      PRK12270
      Location:187 → 275
      kgd; alpha-ketoglutarate decarboxylase; Reviewed

    5. NM_001298824.1 → NP_001285753.1  A kinase anchor protein 200, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BM5
      Conserved Domains (1) summary
      PRK10811
      Location:492 → 671
      rne; ribonuclease E; Reviewed

    6. NM_164820.2 → NP_723395.1  A kinase anchor protein 200, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723395.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U7E6
      Related
      FBpp0079280
      Conserved Domains (1) summary
      PRK10811
      Location:144 → 319
      rne; ribonuclease E; Reviewed

    7. NM_058111.4 → NP_477459.1  A kinase anchor protein 200, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477459.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U7E6
      Related
      FBpp0079281
      Conserved Domains (1) summary
      PRK10811
      Location:144 → 319
      rne; ribonuclease E; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BM5 Q86BM5
    Q8SY32 Q8SY32
    Q9U7E6 Q9U7E6
    Q9VLL3.3 Q9VLL3

    Gene LinkOut

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