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    AttA Attacin-A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36636, updated on 17-Dec-2024

    Summary

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    Official Symbol
    AttAprovided by FlyBase
    Official Full Name
    Attacin-Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0012042
    Locus tag
    Dmel_CG10146
    See related
    AllianceGenome:FB:FBgn0012042
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AHA; anon-WO0140519.5; att; Att; ATT; att A; Att A; Att-A; attA; AttaA; attacin; Attacin A; AttacinA; BcDNA:LP05763; CG10146; Dmel\CG10146
    Summary
    Involved in defense response to other organism and response to hyperoxia. Located in extracellular space. Is expressed in embryonic/larval hemolymph. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AttA in Genome Data Viewer
    Location:
    51C1-51C1; 2-72 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14747362..14748215)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10634867..10635720)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene jet fuel Neighboring gene Drosocin Neighboring gene Attacin-B Neighboring gene Regulatory particle non-ATPase 6 Neighboring gene aveugle

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of early genes in the Drosophila immune response by PCR-based differential display: the Attacin A gene and the evolution of attacin-like proteins. Asling B, et al. Insect Biochem Mol Biol, 1995 Apr. PMID 7742836
    2. Molecular cloning, expression in Escherichia coli of Attacin A gene from Drosophila and detection of biological activity. Wang LN, et al. Mol Biol Rep, 2010 Jun. PMID 19711194
    3. Growing bacteria shed elicitors of Drosophila humoral immunity. Karlsson J, et al. J Innate Immun, 2012. PMID 21829001
    4. Cordycepin, a metabolite of Cordyceps militaris, reduces immune-related gene expression in insects. Woolley VC, et al. J Invertebr Pathol, 2020 Nov. PMID 33022282, Free PMC Article
    5. The effect of mating on immunity can be masked by experimental piercing in female Drosophila melanogaster. Wigby S, et al. J Insect Physiol, 2008 Feb. PMID 18068720, Free PMC Article

    See all (484) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that in response to infection Drosophila egg expressed several immune genes including AttacinA (CG10146), CecropinA1 (CG1365) and CecropinB (CG1878).
      Title: Immune competence in insect eggs depends on the extraembryonic serosa.
    2. the Drosophila melanogaster attacin C Pro-domain has antibacterial properties
      Title: Primary structure and in vitro antibacterial properties of the Drosophila melanogaster attacin C Pro-domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in antibacterial humoral response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to bacterium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to insect IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in humoral immune response IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hyperoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Attacin-A
    Names
    AttA-PA
    Attacin-A precursor
    CG10146-PA
    attacin
    attacin A
    attacinA
    attackin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14747362..14748215
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079021.5 → NP_523745.1  Attacin-A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523745.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P45884, Q9V750
      Related
      FBpp0086567
      Conserved Domains (2) summary
      pfam03768
      Location:34 → 99
      Attacin_N; Attacin, N-terminal region
      pfam03769
      Location:101 → 220
      Attacin_C; Attacin, C-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P45884.1 P45884
    Q95NP8 Q95NP8
    Q95SX2 Q95SX2
    Q95U97 Q95U97
    Q95U98 Q95U98
    Q95U99 Q95U99
    Q95UA0 Q95UA0
    Q95UA1 Q95UA1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
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