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    Y54E2A.4 Activating signal cointegrator 1 complex subunit 3;SEC63 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190256, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y54E2A.4
    Official Full Name
    Activating signal cointegrator 1 complex subunit 3;SEC63 domain-containing protein
    Primary source
    WormBase:WBGene00013189
    Locus tag
    CELE_Y54E2A.4
    See related
    AllianceGenome:WB:WBGene00013189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and helicase activity. Predicted to be involved in DNA duplex unwinding and gene expression. Is expressed in reproductive system. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y54E2A.4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (14754622..14778149)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Nonsense-mediated mRNA decay factor SMG9 Neighboring gene Transforming acid coiled-coil-containing protein 1 Neighboring gene Secreted protein Neighboring gene Uncharacterized protein Neighboring gene Bromodomain associated domain-containing protein;Coiled-coil domain-containing protein 137 Neighboring gene Vitelline membrane outer layer protein 1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
    2. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Activating signal cointegrator 1 complex subunit 3;SEC63 domain-containing protein
    NP_001293535.1
    • Confirmed by transcript evidence
    NP_001293536.1
    • Confirmed by transcript evidence
    NP_497060.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      14754622..14778149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064659.3 → NP_497060.2  Activating signal cointegrator 1 complex subunit 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497060.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWI1
      Conserved Domains (3) summary
      smart00611
      Location:1665 → 2015
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:307 → 1065
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:1179 → 1370
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

    2. NM_001306606.3 → NP_001293535.1  SEC63 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PQS1
      Conserved Domains (3) summary
      smart00611
      Location:97 → 423
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      COG1204
      Location:459 → 1081
      BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
      cd18022
      Location:461 → 652
      DEXHc_ASCC3_2; C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3

    3. NM_001306607.3 → NP_001293536.1  SEC63 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293536.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      U4PDW0
      Conserved Domains (2) summary
      smart00611
      Location:124 → 474
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      PRK02362
      Location:1 → 139
      PRK02362; ATP-dependent DNA helicase
    Nucleotide Protein
    Heading Accession and Version

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