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    wac-1.1 WW domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189782, updated on 2-Nov-2024

    Summary

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    Official Symbol
    wac-1.1
    Official Full Name
    WW domain-containing protein
    Primary source
    WormBase:WBGene00012734
    Locus tag
    CELE_Y40B1A.3
    See related
    AllianceGenome:WB:WBGene00012734
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II complex binding activity and chromatin binding activity. Predicted to be involved in positive regulation of TORC1 signaling and regulation of autophagy. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See wac-1.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (13347066..13359643)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Obg-like ATPase 1 Neighboring gene WW domain-containing protein Neighboring gene Specificity protein transcription factor 3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
    2. DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans. Suen KM, et al. Nat Commun, 2020 Aug 25. PMID 32843637, Free PMC Article
    3. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase II complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of autophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    WW domain-containing protein
    NP_001252144.1
    • Partially confirmed by transcript evidence
    NP_001364501.1
    • Confirmed by transcript evidence
    NP_001364502.1
    • Partially confirmed by transcript evidence
    NP_001364574.1
    • Partially confirmed by transcript evidence
    NP_001364671.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13347066..13359643
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377669.2 → NP_001364671.1  WW domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1NZ12
      Conserved Domains (1) summary
      cd00201
      Location:9 → 38
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

    2. NM_001377668.2 → NP_001364501.1  WW domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MND1
      Conserved Domains (1) summary
      pfam00397
      Location:9 → 36
      WW; WW domain

    3. NM_001377670.2 → NP_001364502.1  WW domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9MRL7

    4. NM_001377671.1 → NP_001364574.1  WW domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XW27

    5. NM_001265215.2 → NP_001252144.1  WW domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001252144.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5WWM0
    Nucleotide Protein
    Heading Accession and Version

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