U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ego-2 BRO1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190251, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ego-2
    Official Full Name
    BRO1 domain-containing protein
    Primary source
    WormBase:WBGene00001215
    Locus tag
    CELE_Y53H1C.2
    See related
    AllianceGenome:WB:WBGene00001215
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in positive regulation of Notch signaling pathway and protein localization to basolateral plasma membrane. Located in cytoplasm and nucleus. Is expressed widely. Orthologous to human PTPN23 (protein tyrosine phosphatase non-receptor type 23). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See ego-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    15
    Sequence:
    Chromosome: I; NC_003279.8 (11400143..11416433, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Amino acid transporter Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein of unknown function WSN domain-containing protein Neighboring gene RING-type E3 ubiquitin transferase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Bro1-domain protein, EGO-2, promotes Notch signaling in Caenorhabditis elegans. Liu Y, et al. Genetics, 2007 Aug. PMID 17603118, Free PMC Article
    2. ESCRT-Dependent Cell Death in a Caenorhabditis elegans Model of the Lysosomal Storage Disorder Mucolipidosis Type IV. Huynh JM, et al. Genetics, 2016 Feb. PMID 26596346, Free PMC Article
    3. Enhancers of glp-1, a gene required for cell-signaling in Caenorhabditis elegans, define a set of genes required for germline development. Qiao L, et al. Genetics, 1995 Oct. PMID 8647392, Free PMC Article
    4. An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. Haag A, et al. PLoS Genet, 2014 May. PMID 24785082, Free PMC Article
    5. The LIN-12/Notch signaling pathway and its regulation. Kimble J, et al. Annu Rev Cell Dev Biol, 1997. PMID 9442877

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to late endosome transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multivesicular body sorting pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Notch signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein localization to basolateral plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    BRO1 domain-containing protein
    NP_001076622.2
    • Confirmed by transcript evidence
    NP_001251634.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11400143..11416433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083153.6 → NP_001076622.2  BRO1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076622.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBN5
      Conserved Domains (4) summary
      cd09234
      Location:386 → 722
      V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
      PRK07764
      Location:840 → 1227
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      PRK12323
      Location:1158 → 1299
      PRK12323; DNA polymerase III subunit gamma/tau
      cl14649
      Location:2 → 381
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

    2. NM_001264705.3 → NP_001251634.1  BRO1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251634.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H8ESG1
      Conserved Domains (4) summary
      cd09234
      Location:386 → 722
      V_HD-PTP_like; Protein-interacting V-domain of mammalian His-Domain type N23 protein tyrosine phosphatase and related domains
      PRK07764
      Location:840 → 1227
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      PRK12323
      Location:1158 → 1308
      PRK12323; DNA polymerase III subunit gamma/tau
      cl14649
      Location:2 → 381
      BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools