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    bdg bedraggled [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36747, updated on 9-Dec-2024

    Summary

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    Official Symbol
    bdgprovided by FlyBase
    Official Full Name
    bedraggledprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034049
    Locus tag
    Dmel_CG8291
    See related
    AllianceGenome:FB:FBgn0034049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8291; Dmel\CG8291
    Summary
    Predicted to enable neurotransmitter:sodium symporter activity. Involved in R3/R4 cell fate commitment. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; imaginal disc; larval central nervous system; larval ventral nerve cord; and mesectoderm anlage. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See bdg in Genome Data Viewer
    Location:
    52D2-52D2; 2-76 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15923040..15931935, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11810545..11819440, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene slit Neighboring gene antisense RNA:CR46471 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44373 Neighboring gene Death-associated inhibitor of apoptosis 2 Neighboring gene bunker gear Neighboring gene Myelodysplasia/myeloid leukemia factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bedraggled, a putative transporter, influences the tissue polarity complex during the R3/R4 fate decision in the Drosophila eye. Rawls AS, et al. Genetics, 2007 Sep. PMID 17890365, Free PMC Article
    2. The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions. Miller MM, et al. Insect Biochem Mol Biol, 2008 Oct. PMID 18718864, Free PMC Article
    3. Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster. Thimgan MS, et al. J Exp Biol, 2006 Sep. PMID 16916974
    4. The Drosophila inhibitor of apoptosis (IAP) DIAP2 is dispensable for cell survival, required for the innate immune response to gram-negative bacterial infection, and can be negatively regulated by the reaper/hid/grim family of IAP-binding apoptosis inducers. Huh JR, et al. J Biol Chem, 2007 Jan 19. PMID 17068333
    5. Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses. Vinci G, et al. PLoS One, 2008 Aug 6. PMID 18682733, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotransmitter transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables neurotransmitter:sodium symporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in R3/R4 cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in R3/R4 cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neurotransmitter transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in neurotransmitter transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bedraggled
    Names
    CG8291-PA
    CG8291-PB
    CG8291-PC
    CG8291-PD
    bdg-PA
    bdg-PB
    bdg-PC
    bdg-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15923040..15931935 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299540.1 → NP_001286469.1  bedraggled, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286469.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MSR0
      Conserved Domains (1) summary
      cd06857
      Location:501 → 975
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_137220.3 → NP_611064.2  bedraggled, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611064.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LF97, Q0E961
      UniProtKB/TrEMBL
      Q8MSR0
      Related
      FBpp0086433
      Conserved Domains (1) summary
      cd06857
      Location:501 → 976
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_176181.2 → NP_788361.1  bedraggled, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788361.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LF97, Q0E961
      UniProtKB/TrEMBL
      Q8MSR0
      Related
      FBpp0086435
      Conserved Domains (1) summary
      cd06857
      Location:501 → 976
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_166121.2 → NP_725499.2  bedraggled, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725499.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0B4LF97, Q0E961
      UniProtKB/TrEMBL
      Q8MSR0
      Related
      FBpp0086434, FBtr0087299
      Conserved Domains (1) summary
      cd06857
      Location:501 → 976
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E961.1 Q0E961
    Q8MSR0 Q8MSR0

    Gene LinkOut

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