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    F13G3.10 Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 3565846, updated on 9-Dec-2024

    Summary

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    Official Symbol
    F13G3.10
    Official Full Name
    Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein
    Primary source
    WormBase:WBGene00008768
    Locus tag
    CELE_F13G3.10
    See related
    AllianceGenome:WB:WBGene00008768
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in negative regulation of apoptotic process and protein stabilization. Orthologous to human HYPK (huntingtin interacting protein K). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See F13G3.10 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (7313625..7314279, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Innexin eat-5 Neighboring gene MIF-like protein mif-3 Neighboring gene Uncharacterized protein Neighboring gene Guanine nucleotide-binding protein subunit beta-2 Neighboring gene Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Ayyadevara S, et al. Aging Cell, 2015 Feb. PMID 25510159, Free PMC Article
    2. Structural insights into pro-aggregation effects of C. elegans CRAM-1 and its human ortholog SERF2. Balasubramaniam M, et al. Sci Rep, 2018 Oct 5. PMID 30291272, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein
    NP_001122452.1
    • Confirmed by transcript evidence
    NP_001359719.1
    • Confirmed by transcript evidence
    NP_001379130.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7313625..7314279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373051.2 → NP_001359719.1  Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECM7
      Conserved Domains (1) summary
      cd14361
      Location:49 → 89
      UBA_HYPK; UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins

    2. NM_001392546.1 → NP_001379130.1  Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECC1
      Conserved Domains (2) summary
      cd14361
      Location:54 → 94
      UBA_HYPK; UBA-like domain found in Huntingtin-interacting protein K (HYPK) and similar proteins
      pfam15921
      Location:6 → 95
      CCDC158; Coiled-coil domain-containing protein 158

    3. NM_001128980.4 → NP_001122452.1  Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122452.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B2D6L9
      Conserved Domains (1) summary
      cl21463
      Location:1 → 30
      UBA_like_SF; UBA domain-like superfamily
    Nucleotide Protein
    Heading Accession and Version

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