dyci-1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dyci-1
Official Full Name: WD_REPEATS_REGION domain-containing protein
Primary source: WormBase:WBGene00015927
Locus tag: CELE_C17H12.1
See related: AllianceGenome:WB:WBGene00015927
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in transport along microtubule. Predicted to be part of cytoplasmic dynein complex. Is expressed in ciliated neurons. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1) and DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dyci-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 13

Sequence:: Chromosome: IV; NC_003282.8 (6779845..6785272, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans.
Title: Dynein intermediate chains DYCI-1 and WDR-60 have specific functions in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C17H12.1 (e-PCR)
- UniSTS:309109

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD_REPEATS_REGION domain-containing protein

NP_001360494.1

Confirmed by transcript evidence

NP_001370459.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

6779845..6785272 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001372852.3 → NP_001360494.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A486WV95

Conserved Domains (2) summary

sd00039
Location:282 → 329

7WD40; WD40 repeat [structural motif]

cl29593
Location:378 → 607

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001383110.2 → NP_001370459.1 WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

O45087

Conserved Domains (2) summary

sd00039
Location:286 → 333

7WD40; WD40 repeat [structural motif]

cl29593
Location:382 → 611

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...