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    cmtr-1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [ Caenorhabditis elegans ]

    Gene ID: 175156, updated on 9-Dec-2024

    Summary

    Official Symbol
    cmtr-1
    Official Full Name
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    Primary source
    WormBase:WBGene00013160
    Locus tag
    CELE_Y53F4B.13
    See related
    AllianceGenome:WB:WBGene00013160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping. Predicted to be active in cytoplasm and nucleus. Orthologous to human CMTR1 (cap methyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See cmtr-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    11
    Sequence:
    Chromosome: II; NC_003280.10 (15026114..15037854)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Amino acid permease/ SLC12A domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein PET100 homolog, mitochondrial;TPX2 domain-containing protein Neighboring gene TRIP4/RQT4 C2HC5-type zinc finger domain-containing protein Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in 7-methylguanosine mRNA capping IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in 7-methylguanosine mRNA capping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA modification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
    NP_001254457.1
    • Confirmed by transcript evidence
    NP_001254458.1
    • Confirmed by transcript evidence
    NP_001254459.1
    • Partially confirmed by transcript evidence
    NP_001254460.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      15026114..15037854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267528.2NP_001254457.1  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254457.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      H8ESH8, H8ESH9, H8ESI0, H8ESI1, Q9NAA5
      Conserved Domains (2) summary
      pfam01585
      Location:89130
      G-patch; G-patch domain
      pfam01728
      Location:237463
      FtsJ; FtsJ-like methyltransferase
    2. NM_001267529.3NP_001254458.1  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAA5
      Conserved Domains (2) summary
      pfam01585
      Location:89130
      G-patch; G-patch domain
      pfam01728
      Location:237457
      FtsJ; FtsJ-like methyltransferase
    3. NM_001267530.3NP_001254459.1  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAA5
      Conserved Domains (2) summary
      pfam01585
      Location:89130
      G-patch; G-patch domain
      pfam01728
      Location:237463
      FtsJ; FtsJ-like methyltransferase
    4. NM_001267531.3NP_001254460.1  Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254460.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NAA5
      Conserved Domains (2) summary
      pfam01585
      Location:89130
      G-patch; G-patch domain
      pfam01728
      Location:237463
      FtsJ; FtsJ-like methyltransferase