gammaTub37C gamma-Tubulin at 37C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gammaTub37Cprovided by FlyBase
Official Full Name: gamma-Tubulin at 37Cprovided by FlyBase
Primary source: FLYBASE:FBgn0010097
Locus tag: Dmel_CG17566
See related: AllianceGenome:FB:FBgn0010097
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17566; D.m.GAMMA-37C; Dmel\CG17566; fs(2)TW1; fs(2)TWI; fsTW1; g-Tubulin; gamma Tub37CD; gamma tubulin; gamma-tub; gamma-Tub; gamma-tub37C; gamma-Tub37C; gamma-tub37CD; gamma-tubulin; gamma-tubulin37C; gammatub; gammaTub; gammaTUB; gammaTub2; gammatub37C; gammaTub37c; gammaTUB37C; gammaTub37CD; gammatubulin; gamma[mat]; GTU88*; PL10; Rb1011; Tub37C; Tub3B; TW1
Summary: Enables GTP binding activity. Involved in meiotic chromosome segregation; mitotic spindle-templated microtubule nucleation; and oocyte nucleus migration involved in oocyte dorsal/ventral axis specification. Located in centrosome; cytoplasm; and meiotic spindle. Part of gamma-tubulin ring complex. Is expressed in adult head and organism. Orthologous to human TUBG2 (tubulin gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 37C7-37C7; 2-54 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19183863..19185726, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19183863..19185726, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

conclusive demonstration of a role for gammaTub37C in both the formation of the anastral meiosis I spindle and in the proper attachment of kinetochore microtubules
Title: Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes.
Results show that that several MTs originate from acentriolar microtubule-organizing centers (aMTOCs) that contain gamma-tubulin and require Centrosomin (Cnn) for normal architecture and function.
Title: Microtubule cytoskeleton remodeling by acentriolar microtubule-organizing centers at the entry and exit from mitosis in Drosophila somatic cells.
This indicates a role for Dgrip84 in regulating the activity and/or the location of the gamma-tubulin complexes formed with gammaTub37CD and gammaTub23C.
Title: Distinct Dgrip84 isoforms correlate with distinct gamma-tubulins in Drosophila.
Gamma-tubulin37C and gamma-tubulin ring complex protein 75 are essential for bicoid RNA localization during drosophila oogenesis
Title: Gamma-tubulin37C and gamma-tubulin ring complex protein 75 are essential for bicoid RNA localization during drosophila oogenesis.
gamma-tubulin is required for female germ-cell proliferation and that the two gamma-tubulins present in Drosophila are functionally equivalent during female germ-cell development and oogenesis.
Title: gamma-Tubulin function during female germ-cell development and oogenesis in Drosophila.
constantly detected at the centrosome and absent in the mitotic spindle
Title: Differential properties of the two Drosophila gamma-tubulin isotypes.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables microtubule nucleator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in attachment of meiotic spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoplasmic microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in meiotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IEA Inferred from Electronic Annotation more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle-templated microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle assembly involved in female meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-tubulin complex	IEA Inferred from Electronic Annotation more info
part_of gamma-tubulin ring complex	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma-tubulin ring complex	IDA Inferred from Direct Assay more info	PubMed
located_in meiotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in spindle	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: gamma-Tubulin at 37C

Names: 37CD gamma-tubulin; CG17566-PA; CG17566-PB; female sterile(2)Ted wright 1; g-tubulin37C; gama-tubulin; gamma Tubulin2; gamma tubulin; gamma tubulin at 37C; gamma-Tubulin; gamma-Tubulin 37C; gamma-tubulin (37C); gamma-tubulin-2; gamma-tubulin37C; gammaTub37C-PA; gammaTub37C-PB; gammatubulin; maternal gamma-tubulin; tubulin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

19183863..19185726 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273636.1 → NP_001260565.1 gamma-Tubulin at 37C, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260565.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77160, P42271, Q9V476

UniProtKB/TrEMBL

M9PDN9

Conserved Domains (2) summary

PLN00222
Location:1 → 447

PLN00222; tubulin gamma chain; Provisional

cd02188
Location:4 → 436

gamma_tubulin; The gamma-tubulin family
NM_057574.5 → NP_476922.1 gamma-Tubulin at 37C, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476922.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O77160, P42271, Q9V476

UniProtKB/TrEMBL

M9PDN9

Related

FBpp0080769

Conserved Domains (2) summary

PLN00222
Location:1 → 447

PLN00222; tubulin gamma chain; Provisional

cd02188
Location:4 → 436

gamma_tubulin; The gamma-tubulin family