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    tbx-37 T-box protein 37 [ Caenorhabditis elegans ]

    Gene ID: 189977, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tbx-37
    Official Full Name
    T-box protein 37
    Primary source
    WormBase:WBGene00006556
    Locus tag
    CELE_Y47D3A.12
    See related
    AllianceGenome:WB:WBGene00006556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in pharynx development. Located in nucleus. Is expressed in several structures, including ABalaa; ABalap; ABalpa; ABalpp; and ABaraa. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; bone disease (multiple); and cleft palate (multiple). Orthologous to several human genes including MGA (MAX dimerization protein MGA); TBX15 (T-box transcription factor 15); and TBX22 (T-box transcription factor 22). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tbx-37 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (11224808..11227125, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ABC transporter domain-containing protein Neighboring gene DUF4349 domain-containing protein Neighboring gene Elongation of very long chain fatty acids protein;Very-long-chain 3-oxoacyl-CoA synthase Neighboring gene AcidPPc domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. pop-1/TCF, ref-2/ZIC and T-box factors regulate the development of anterior cells in the C. elegans embryo. Rumley JD, et al. Dev Biol, 2022 Sep. PMID 35660370, Free PMC Article
    2. The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos. Good K, et al. Development, 2004 May. PMID 15056620
    3. Early embryonic programming of neuronal left/right asymmetry in C. elegans. Poole RJ, et al. Curr Biol, 2006 Dec 5. PMID 17141609
    4. Role of T-box gene tbx-2 for anterior foregut muscle development in C. elegans. Smith PA, et al. Dev Biol, 2007 Feb 1. PMID 17005176, Free PMC Article
    5. The conserved role and divergent regulation of foxa, a pan-eumetazoan developmental regulatory gene. de-Leon SB. Dev Biol, 2011 Sep 1. PMID 21130759, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that TBX-37 and TBX-38 play a key role in distinguishing the outcomes of two sequential Glp-1/Notch-mediated interactions.
      Title: The T-box transcription factors TBX-37 and TBX-38 link GLP-1/Notch signaling to mesoderm induction in C. elegans embryos.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in developmental process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pharynx development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    T-box protein 37
    NP_499444.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11224808..11227125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067043.6 → NP_499444.2  T-box protein 37 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499444.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U2C9
      Conserved Domains (1) summary
      cd00182
      Location:9 → 199
      TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U2C9.2

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