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    strm-1 Sterol 4-C-methyltransferase strm-1 [ Caenorhabditis elegans ]

    Gene ID: 175358, updated on 9-Dec-2024

    Summary

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    Official Symbol
    strm-1
    Official Full Name
    Sterol 4-C-methyltransferase strm-1
    Primary source
    WormBase:WBGene00019198
    Locus tag
    CELE_H14E04.1
    See related
    AllianceGenome:WB:WBGene00019198
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables S-adenosylmethionine-dependent methyltransferase activity. Involved in regulation of dauer larval development. Predicted to be active in endoplasmic reticulum. Is expressed in hypodermis and pharynx. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See strm-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    7
    Sequence:
    Chromosome: III; NC_003281.10 (2402070..2406335)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Bestrophin homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Cyclin-C Neighboring gene 39S ribosomal protein L30, mitochondrial Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Galectin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans. Hannich JT, et al. Dev Cell, 2009 Jun. PMID 19531354
    2. Comparative bioinformatic analysis suggests that specific dauer-like signalling pathway components regulate Toxocara canis development and migration in the mammalian host. Ma G, et al. Parasit Vectors, 2019 Jan 14. PMID 30642380, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A methyltransferase, STRM-1, that modulates dafachronic acid levels and thus dauer formation, was identified.
      Title: Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol 24-C-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dauer larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sterol 4-C-methyltransferase strm-1
    NP_497549.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      2402070..2406335
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065148.7 → NP_497549.2  Sterol 4-C-methyltransferase strm-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497549.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9TYP1
      Conserved Domains (1) summary
      pfam08241
      Location:100 → 197
      Methyltransf_11; Methyltransferase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9TYP1.2

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