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    hyl-2 Ceramide synthase hyl-2 [ Caenorhabditis elegans ]

    Gene ID: 180743, updated on 9-Dec-2024

    Summary

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    Official Symbol
    hyl-2
    Official Full Name
    Ceramide synthase hyl-2
    Primary source
    WormBase:WBGene00002044
    Locus tag
    CELE_K02G10.6
    See related
    AllianceGenome:WB:WBGene00002044
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable sphingosine N-acyltransferase activity. Predicted to be involved in ceramide biosynthetic process. Predicted to be located in membrane. Is expressed in head; hypodermis; intestine; tail; and terminal bulb. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 9. Orthologous to several human genes including CERS6 (ceramide synthase 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See hyl-2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (4696754..4699461, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Solute carrier organic anion transporter family member Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondria to nucleus signaling and the role of ceramide in its integration into the suite of cell quality control processes during aging. Jazwinski SM. Ageing Res Rev, 2015 Sep. PMID 25555678, Free PMC Article
    2. Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition. Zhu H, et al. J Biol Chem, 2024 Jun. PMID 38677510, Free PMC Article
    3. The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging. Staab TA, et al. Aging (Albany NY), 2023 Feb 13. PMID 36787434, Free PMC Article
    4. Protection of C. elegans from anoxia by HYL-2 ceramide synthase. Menuz V, et al. Science, 2009 Apr 17. PMID 19372430
    5. High-glucose diets induce mitochondrial dysfunction in Caenorhabditis elegans. Alcántar-Fernández J, et al. PLoS One, 2019. PMID 31846489, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition.
      Title: Loss of the ceramide synthase HYL-2 from Caenorhabditis elegans impairs stress responses and alters sphingolipid composition.
    2. data indicate that specific ceramides produced by HYL-2 confer resistance to anoxia
      Title: Protection of C. elegans from anoxia by HYL-2 ceramide synthase.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    NOT enables sphingosine N-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sphingosine N-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ceramide synthase hyl-2
    NP_508803.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4696754..4699461 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_076402.9 → NP_508803.3  Ceramide synthase hyl-2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508803.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7Z139
      Conserved Domains (1) summary
      smart00724
      Location:86 → 298
      TLC; TRAM, LAG1 and CLN8 homology domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z139.1

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