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    lnp-1 Endoplasmic reticulum junction formation protein lunapark;Endoplasmic reticulum junction formation protein lunapark-1 [ Caenorhabditis elegans ]

    Gene ID: 180731, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lnp-1
    Official Full Name
    Endoplasmic reticulum junction formation protein lunapark;Endoplasmic reticulum junction formation protein lunapark-1
    Primary source
    WormBase:WBGene00015492
    Locus tag
    CELE_C05E11.1
    See related
    AllianceGenome:WB:WBGene00015492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable metal ion binding activity. Involved in several processes, including regulation of egg-laying behavior; synapse assembly; and synaptic vesicle transport. Located in several cellular components, including neuron projection; neuronal cell body; and synaptic vesicle. Is expressed in hypodermis; muscle cell; and neurons. Orthologous to human LNPK (lunapark, ER junction formation factor). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lnp-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (4588762..4590446)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DUF19 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene FMRF-Like Peptide Neighboring gene E3 ubiquitin-protein ligase RING2 homolog spat-3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The evolutionarily conserved gene LNP-1 is required for synaptic vesicle trafficking and synaptic transmission. Ghila L, et al. Eur J Neurosci, 2008 Feb. PMID 18279315
    2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum tubular network maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of endoplasmic reticulum tubular network organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synapse structure or activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum tubular network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum tubular network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum tubular network membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Endoplasmic reticulum junction formation protein lunapark;Endoplasmic reticulum junction formation protein lunapark-1
    NP_001348785.1
    • Confirmed by transcript evidence
    NP_508788.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      4588762..4590446
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001361798.3 → NP_001348785.1  Endoplasmic reticulum junction formation protein lunapark [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2K5AU06
      Conserved Domains (1) summary
      pfam10058
      Location:215 → 265
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein

    2. NM_076387.7 → NP_508788.1  Endoplasmic reticulum junction formation protein lunapark-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508788.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q17667
      Conserved Domains (1) summary
      pfam10058
      Location:215 → 265
      zinc_ribbon_10; Predicted integral membrane zinc-ribbon metal-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17667.2

    Gene LinkOut

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