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    CNPYb Canopy b [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40084, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CNPYbprovided by FlyBase
    Official Full Name
    Canopy bprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036847
    Locus tag
    Dmel_CG11577
    See related
    AllianceGenome:FB:FBgn0036847
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.323; CG11577; Dmel\CG11577
    Summary
    Enables protein-folding chaperone binding activity. Involved in chaperone-mediated protein folding. Located in endomembrane system. Is expressed in organism. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 60. Orthologous to several human genes including CNPY4 (canopy FGF signaling regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CNPYb in Genome Data Viewer
    Location:
    75F7-75F7; 3-45 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19094890..19096217, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19087990..19089317, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45386 Neighboring gene Misexpression suppressor of ras 6 Neighboring gene NAD(P)HX dehydratase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila canopy b is a cochaperone of glycoprotein 93. Morales C, et al. J Biol Chem, 2017 Apr 21. PMID 28275054, Free PMC Article
    2. Investigating Developmental and Epileptic Encephalopathy Using Drosophila melanogaster. Takai A, et al. Int J Mol Sci, 2020 Sep 3. PMID 32899411, Free PMC Article
    3. A single-cell atlas and lineage analysis of the adult Drosophila ovary. Rust K, et al. Nat Commun, 2020 Nov 6. PMID 33159074, Free PMC Article
    4. Mitochondrial perturbation in immune cells enhances cell-mediated innate immunity in Drosophila. Vesala L, et al. BMC Biol, 2024 Mar 13. PMID 38475850, Free PMC Article
    5. Mapping organelle proteins and protein complexes in Drosophila melanogaster. Tan DJ, et al. J Proteome Res, 2009 Jun. PMID 19317464

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    canopy b
    Names
    CG11577-PA
    CNPYb-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19094890..19096217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140832.4 → NP_649089.2  canopy b [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649089.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95S24, Q9VVW7
      Related
      FBpp0074801
      Conserved Domains (1) summary
      pfam11938
      Location:35 → 184
      DUF3456; TLR4 regulator and MIR-interacting MSAP
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95S24 Q95S24
    Q9VVW7 Q9VVW7

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