fzy-1 WD repeat-containing protein fzy-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fzy-1
Official Full Name: WD repeat-containing protein fzy-1
Primary source: WormBase:WBGene00001511
Locus tag: CELE_ZK177.6
See related: AllianceGenome:WB:WBGene00001511
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in several processes, including metaphase/anaphase transition of meiosis I; polar body extrusion after meiotic divisions; and polarity specification of anterior/posterior axis. Located in condensed chromosome and cytoplasm. Is expressed in germ cell. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 109. Orthologous to human CDC20 (cell division cycle 20) and FZR1 (fizzy and cell division cycle 20 related 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See fzy-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 10

Sequence:: Chromosome: II; NC_003280.10 (5501633..5503908)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses.
Title: BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses.
A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores.
Title: A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores.
the cdc-20 gain-of-function mutant cdc-20/fzy-1(av15), which is refractory to the cell cycle delay conferred by the spindle checkpoint, showed phenotypes similar to bub-3 and san-1 mutants. We speculate that BUB-3 is involved in the DNA damage response through regulation of cell cycle timing.
Title: Caenorhabditis elegans BUB-3 and SAN-1/MAD3 Spindle Assembly Checkpoint Components Are Required for Genome Stability in Response to Treatment with Ionizing Radiation.
Movement of MEI-1-depleted spindles was dependent on fzy-1, a regulator of the metaphase/anaphase transition.
Title: MEI-1/katanin is required for translocation of the meiosis I spindle to the oocyte cortex in C elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZK177.7 (e-PCR)
- UniSTS:320814

ZK177.6 (e-PCR)
- UniSTS:310449

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables anaphase-promoting complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables anaphase-promoting complex binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin ligase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in metaphase/anaphase transition of meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polar body extrusion after meiotic divisions	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in polarity specification of anterior/posterior axis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of anaphase-promoting complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: WD repeat-containing protein fzy-1

NP_495051.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5501633..5503908

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062650.8 → NP_495051.1 WD repeat-containing protein fzy-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495051.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q09373, Q09661

Conserved Domains (3) summary

COG2319
Location:197 → 490

WD40; WD40 repeat [General function prediction only]

sd00039
Location:225 → 268

7WD40; WD40 repeat [structural motif]

cl02567
Location:221 → 484

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...