nos-2 Nanos-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: nos-2
Official Full Name: Nanos-type domain-containing protein
Primary source: WormBase:WBGene00003784
Locus tag: CELE_ZK1127.1
See related: AllianceGenome:WB:WBGene00003784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable mRNA binding activity and zinc ion binding activity. Involved in oogenesis and regulation of cell cycle. Located in cytoplasm. Is expressed in P0; P4; Z2; and Z3. Human ortholog(s) of this gene implicated in spermatogenic failure 12. Orthologous to human NANOS1 (nanos C2HC-type zinc finger 1); NANOS2 (nanos C2HC-type zinc finger 2); and NANOS3 (nanos C2HC-type zinc finger 3). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See nos-2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 5

Sequence:: Chromosome: II; NC_003280.10 (7065618..7067051)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that nos-1 and nos-2 activity is required in primordial germ cells to silence maternal transcripts inherited from the oocyte. We identify maternal lin-15B as a critical target of Nanos regulation that must be turned-over to establish MES methyltransferase dominance in primordial germ cells.
Title: Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.
xnd-1 defines a new branch for PGC development that functions redundantly with nos-2 and nos-1 to promote germline fates by maintaining transcriptional quiescence and regulating germ cell proliferation
Title: A germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans.
Data indicate that meg-1 and meg-2 differentially interact with the nanos family nos-1, nos-2 and nos-3 for germ cell proliferaiton.
Title: C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.
Temporal changes in the relative concentrations of POS-1 and SPN-4, through their effect on the translational status of maternal mRNAs such as nos-2, initiate germ cell-specific developmental programs in C. elegans.
Title: Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells.
Inhibition of translation is repressed in early blastomeres and depends on a region in the nos-2 3'UTR.
Title: Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T02G5.6 (e-PCR)
- UniSTS:321034

ZK1127.1 (e-PCR)
- UniSTS:313672

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in germ cell development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in perinuclear region of cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Nanos-type domain-containing protein

NP_495452.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7065618..7067051

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063051.7 → NP_495452.1 Nanos-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495452.1

Status: REVIEWED

UniProtKB/TrEMBL

Q23406

Conserved Domains (1) summary

pfam05741
Location:167 → 212

zf-nanos; Nanos RNA binding domain