icpp-55 Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: icpp-55
Official Full Name: Aminopeptidase P N-terminal domain-containing protein
Primary source: WormBase:WBGene00020088
Locus tag: CELE_R119.2
See related: AllianceGenome:WB:WBGene00020088
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable aminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in nephronophthisis-like nephropathy 1. Orthologous to human XPNPEP3 (X-prolyl aminopeptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See icpp-55 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (368270..373465, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R119.2 (e-PCR)
- UniSTS:319573

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables aminopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metalloaminopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Aminopeptidase P N-terminal domain-containing protein

NP_001417605.1

Confirmed by transcript evidence

NP_490725.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

368270..373465 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058324.5 → NP_490725.3 Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_490725.3

Status: REVIEWED

UniProtKB/TrEMBL

O61710

Conserved Domains (2) summary

pfam05195
Location:20 → 149

AMP_N; Aminopeptidase P, N-terminal domain

cl00279
Location:188 → 427

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...
NM_001430679.1 → NP_001417605.1 Aminopeptidase P N-terminal domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED