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    che-1 C2H2-type domain-containing protein;Transcription factor che-1 [ Caenorhabditis elegans ]

    Gene ID: 183847, updated on 9-Dec-2024

    Summary

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    Official Symbol
    che-1
    Official Full Name
    C2H2-type domain-containing protein;Transcription factor che-1
    Primary source
    WormBase:WBGene00000483
    Locus tag
    CELE_C55B7.12
    See related
    AllianceGenome:WB:WBGene00000483
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including response to alkaline pH; response to lithium ion; and response to methionine. Predicted to be active in nucleus. Is expressed in ASEL and ASER. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See che-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (6517529..6520918, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase Neighboring gene Protein OSCP1 Neighboring gene ATP-dependent RNA helicase glh-2 Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class Z Neighboring gene ncRNA Neighboring gene protein of unknown function DX domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adverse effects of metal exposure on chemotaxis towards water-soluble attractants regulated mainly by ASE sensory neuron in nematode Caenorhabditis elegans. Xing X, et al. J Environ Sci (China), 2009. PMID 20131599
    2. Coordinated control of terminal differentiation and restriction of cellular plasticity. Patel T, et al. Elife, 2017 Apr 19. PMID 28422646, Free PMC Article
    3. Mechanism of life-long maintenance of neuron identity despite molecular fluctuations. Traets JJ, et al. Elife, 2021 Dec 15. PMID 34908528, Free PMC Article
    4. Transcription factor autoregulation is required for acquisition and maintenance of neuronal identity. Leyva-Díaz E, et al. Development, 2019 Jun 21. PMID 31227642, Free PMC Article
    5. Human Endogenous Retrovirus K (HERV-K) can drive gene expression as a promoter in Caenorhabditis elegans. Durnaoglu S, et al. BMB Rep, 2020 Nov. PMID 32867919, Free PMC Article

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of life-long maintenance of neuron identity despite molecular fluctuations.
      Title: Mechanism of life-long maintenance of neuron identity despite molecular fluctuations.
    2. che-1 autoregulation is indeed required to maintain the differentiated state of the ASE neurons but that it is also required to amplify che-1 expression during embryonic development to reach an apparent minimal threshold to initiate the ASE differentiation program.
      Title: Transcription factor autoregulation is required for acquisition and maintenance of neuronal identity.
    3. through ectopic expression of single transcription factors (che-1) study found the identity of mitotic germ cells can be directly converted into that of specific neuron types; this reprogramming requires removal of LIN-53
      Title: Direct conversion of C. elegans germ cells into specific neuron types.
    4. Both lesions map to the cis-regulatory control region of cog-1 and affect a phylogenetically conserved binding site for the C2H2 zinc-finger transcription factor CHE-1.
      Title: Cis-regulatory mutations in the Caenorhabditis elegans homeobox gene locus cog-1 affect neuronal development.
    5. The ASE motif is a binding site for the C2H2 zinc finger TF CHE-1, which is essential for the correct differentiation of the ASE gustatory neuron.
      Title: The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron.
    6. che-1 gene encodes a zinc finger transcription factor required for specification of the chemosensory neurons
      Title: The C. elegans che-1 gene encodes a zinc finger transcription factor required for specification of the ASE chemosensory neurons.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to alkaline pH IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to lithium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to magnesium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to methionine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C2H2-type domain-containing protein;Transcription factor che-1
    NP_001076597.1
    • Confirmed by transcript evidence
    NP_001076598.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6517529..6520918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083129.2 → NP_001076598.1  C2H2-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076598.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0PCD8
      Conserved Domains (3) summary
      sd00017
      Location:168 → 188
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:166 → 188
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:180 → 205
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001083128.1 → NP_001076597.1  Transcription factor che-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q966L8
      Conserved Domains (3) summary
      sd00017
      Location:109 → 129
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:107 → 129
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:121 → 146
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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