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    cyn-8 Peptidyl-prolyl cis-trans isomerase 8 [ Caenorhabditis elegans ]

    Gene ID: 181136, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cyn-8
    Official Full Name
    Peptidyl-prolyl cis-trans isomerase 8
    Primary source
    WormBase:WBGene00000884
    Locus tag
    CELE_D1009.2
    See related
    AllianceGenome:WB:WBGene00000884
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nucleus. Is expressed in intestine and pharynx. Orthologous to human PPIG (peptidylprolyl isomerase G). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cyn-8 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    6
    Sequence:
    Chromosome: X; NC_003284.9 (8911293..8914261)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Fibrinogen C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene tRNA-Gln Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression pattern and functional significance of a divergent nematode cyclophilin in Caenorhabditis elegans. Page AP, et al. Mol Biochem Parasitol, 1999 Apr 30. PMID 10340496
    2. A novel cyclophilin from parasitic and free-living nematodes with a unique substrate- and drug-binding domain. Ma D, et al. J Biol Chem, 2002 Apr 26. PMID 11847225
    3. Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans. Page AP, et al. Biochem J, 1996 Jul 1. PMID 8694762, Free PMC Article
    4. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cyclosporin A binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidyl-prolyl cis-trans isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in protein peptidyl-prolyl isomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Peptidyl-prolyl cis-trans isomerase 8
    NP_509507.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      8911293..8914261
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077106.2 → NP_509507.1  Peptidyl-prolyl cis-trans isomerase 8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_509507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P52016, Q95QQ0
      Conserved Domains (2) summary
      cd06503
      Location:324 → 391
      ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
      cl00197
      Location:10 → 174
      cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52016.2

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