cyp-35D1 putative cytochrome P450 cyp-35D1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cyp-35D1
Official Full Name: putative cytochrome P450 cyp-35D1
Primary source: WormBase:WBGene00008829
Locus tag: CELE_F14H3.10
See related: AllianceGenome:WB:WBGene00008829
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in several diseases, including acoustic neuroma; gastrointestinal system cancer (multiple); leukemia (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2E1 (cytochrome P450 family 2 subfamily E member 1); and CYP2S1 (cytochrome P450 family 2 subfamily S member 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See cyp-35D1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (16069238..16071318)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F14H3.10 (e-PCR)
- UniSTS:309760

F14H3.9 (e-PCR)
- UniSTS:320920

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in organic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative cytochrome P450 cyp-35D1

NP_507044.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16069238..16071318

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074643.2 → NP_507044.1 putative cytochrome P450 cyp-35D1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507044.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45364

Conserved Domains (1) summary

cl12078
Location:35 → 496

p450; Cytochrome P450