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    aman-2 Alpha-mannosidase [ Caenorhabditis elegans ]

    Gene ID: 179632, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aman-2
    Official Full Name
    Alpha-mannosidase
    Primary source
    WormBase:WBGene00010284
    Locus tag
    CELE_F58H1.1
    See related
    AllianceGenome:WB:WBGene00010284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Located in Golgi apparatus. Is expressed in head; hypodermis; intestine; nervous system; and pharynx. Orthologous to several human genes including MAN2A2 (mannosidase alpha class 2A member 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aman-2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    11
    Sequence:
    Chromosome: V; NC_003283.11 (11927661..11933246, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ANK_REP_REGION domain-containing protein;Ubiquitin-like domain-containing protein Neighboring gene ncRNA Neighboring gene Intraflagellar transport protein 52 C-terminal domain-containing protein Neighboring gene Secreted protein Neighboring gene Enolase-phosphatase E1 Neighboring gene Uncharacterized protein Neighboring gene Bursicon

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Synthesis, α-mannosidase inhibition studies and molecular modeling of 1,4-imino-ᴅ-lyxitols and their C-5-altered N-arylalkyl derivatives. Kalník M, et al. Beilstein J Org Chem, 2023. PMID 36925565, Free PMC Article
    2. Specific N-glycans regulate an extracellular adhesion complex during somatosensory dendrite patterning. Rahman M, et al. EMBO Rep, 2022 Jul 5. PMID 35586945, Free PMC Article
    3. Free oligosaccharides in the cytosol of Caenorhabditis elegans are generated through endoplasmic reticulum-golgi trafficking. Kato T, et al. J Biol Chem, 2007 Jul 27. PMID 17537729
    4. A deletion in the golgi alpha-mannosidase II gene of Caenorhabditis elegans results in unexpected non-wild-type N-glycan structures. Paschinger K, et al. J Biol Chem, 2006 Sep 22. PMID 16864579, Free PMC Article
    5. Adaptation of the "in-gel release method" to N-glycome analysis of low-milligram amounts of material. Rendić D, et al. Electrophoresis, 2007 Dec. PMID 18041037

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables alpha-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-mannosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Alpha-mannosidase
    NP_505995.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11927661..11933246 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073594.4 → NP_505995.2  Alpha-mannosidase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505995.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q2PJ74
      Conserved Domains (1) summary
      PLN02701
      Location:142 → 1124
      PLN02701; alpha-mannosidase
    Nucleotide Protein
    Heading Accession and Version

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