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    tab-1 Homeobox domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 185156, updated on 2-Nov-2024

    Summary

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    Official Symbol
    tab-1
    Official Full Name
    Homeobox domain-containing protein
    Primary source
    WormBase:WBGene00006380
    Locus tag
    CELE_F31E8.3
    See related
    AllianceGenome:WB:WBGene00006380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in head neurons; intestine; and lateral ganglion. Orthologous to human BSX (brain specific homeobox). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See tab-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (6803324..6804863)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Clip domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Copper transport protein Neighboring gene DUF4091 domain-containing protein Neighboring gene C2 domain-containing protein;Synaptotagmin-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The NK-2 class homeodomain factor CEH-51 and the T-box factor TBX-35 have overlapping function in C. elegans mesoderm development. Broitman-Maduro G, et al. Development, 2009 Aug. PMID 19605496, Free PMC Article
    2. C. elegans monitor energy status via the AMPK pathway to trigger innate immune responses against bacterial pathogens. Ju S, et al. Commun Biol, 2022 Jun 30. PMID 35773333, Free PMC Article
    3. Neuronal identity control by terminal selectors in worms, flies, and chordates. Hobert O, et al. Curr Opin Neurobiol, 2019 Jun. PMID 30665084
    4. The regulatory content of intergenic DNA shapes genome architecture. Nelson CE, et al. Genome Biol, 2004. PMID 15059258, Free PMC Article
    5. The behavioral genetics of Caenorhabditis elegans. Wolinsky E, et al. Behav Genet, 1990 Mar. PMID 2191646

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox domain-containing protein
    NP_001338827.1
    • Confirmed by transcript evidence
    NP_495392.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      6803324..6804863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001351904.3 → NP_001338827.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1X7RC60
      Conserved Domains (1) summary
      pfam00046
      Location:121 → 174
      Homeobox; Homeobox domain

    2. NM_062991.4 → NP_495392.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19937
      Conserved Domains (1) summary
      pfam00046
      Location:124 → 177
      Homeobox; Homeobox domain
    Nucleotide Protein
    Heading Accession and Version

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