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    tsp-7 Tetraspanin [ Caenorhabditis elegans ]

    Gene ID: 192062, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tsp-7
    Official Full Name
    Tetraspanin
    Primary source
    WormBase:WBGene00006633
    Locus tag
    CELE_T23D8.2
    See related
    AllianceGenome:WB:WBGene00006633
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in DA neuron; head neurons; tail neurons; touch receptor neurons; and ventral cord neurons. Orthologous to human CD63 (CD63 molecule). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tsp-7 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (9969972..9973177, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Neighboring gene ncRNA Neighboring gene Protein mom-5 Neighboring gene Protein LTV1 homolog Neighboring gene Eukaryotic translation initiation factor 3 subunit C

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Integration of heterogeneous functional genomics data in gerontology research to find genes and pathway underlying aging across species. Bubier JA, et al. PLoS One, 2019. PMID 30978202, Free PMC Article
    2. Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons. Razzauti A, et al. Elife, 2021 Sep 17. PMID 34533135, Free PMC Article
    3. Cilia-Derived Extracellular Vesicles in Caenorhabditis Elegans: In Vivo Imaging and Quantification of Extracellular Vesicle Release and Capture. Razzauti A, et al. Methods Mol Biol, 2023. PMID 37140803
    4. A gene expression fingerprint of C. elegans embryonic motor neurons. Fox RM, et al. BMC Genomics, 2005 Mar 21. PMID 15780142, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tetraspanin
    NP_492636.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9969972..9973177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060235.2 → NP_492636.1  Tetraspanin [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492636.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XVI4
      Conserved Domains (2) summary
      cd03165
      Location:104 → 195
      NET-5_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:8 → 223
      Tetraspannin; Tetraspanin family
    Nucleotide Protein
    Heading Accession and Version

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