U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    dhrr-1 G_PROTEIN_RECEP_F2_4 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191374, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    dhrr-1
    Official Full Name
    G_PROTEIN_RECEP_F2_4 domain-containing protein
    Primary source
    WormBase:WBGene00014035
    Locus tag
    CELE_ZK643.3
    See related
    AllianceGenome:WB:WBGene00014035
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in M.vlpaaapp; M.vlpaapaa; M.vrpaaapp; M.vrpaapaa; and head muscle. Human ortholog(s) of this gene implicated in achalasia; isolated growth hormone deficiency; isolated growth hormone deficiency type IB; and obesity. Orthologous to several human genes including ADCYAP1R1 (ADCYAP receptor type I); GLP1R (glucagon like peptide 1 receptor); and GHRHR (growth hormone releasing hormone receptor). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See dhrr-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (8944686..8952953)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Arrestin C-terminal-like domain-containing protein;Arrestin domain-containing protein 15 Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene putative deoxycytidylate deaminase Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene GRound-Like (grd related)

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Family-B G-protein-coupled receptors. Harmar AJ. Genome Biol, 2001. PMID 11790261, Free PMC Article
    2. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
    3. System-wide mapping of peptide-GPCR interactions in C. elegans. Beets I, et al. Cell Rep, 2023 Sep 26. PMID 37656621, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G protein-coupled peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    G_PROTEIN_RECEP_F2_4 domain-containing protein
    NP_001122749.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8944686..8952953
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001129277.5 → NP_001122749.1  G_PROTEIN_RECEP_F2_4 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001122749.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30649, P30650
      UniProtKB/TrEMBL
      A7LPE2
      Conserved Domains (2) summary
      smart00008
      Location:142 → 222
      HormR; Domain present in hormone receptors
      cl21561
      Location:230 → 466
      7tm_4; Olfactory receptor
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools