U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    CysRS Cysteinyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36784, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    CysRSprovided by FlyBase
    Official Full Name
    Cysteinyl-tRNA synthetaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027091
    Locus tag
    Dmel_CG8431
    See related
    AllianceGenome:FB:FBgn0027091
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-cys; BcDNA:LD21177; CARS; CG8431; CRS; dCARS; Dmel\CG8431
    Summary
    Predicted to enable ATP binding activity; cysteine-tRNA ligase activity; and tRNA binding activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic proventriculus; embryonic proventriculus inner layer; and organism. Orthologous to human CARS1 (cysteinyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See CysRS in Genome Data Viewer
    Location:
    52E11-52E11; 2-77 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16143147..16145906)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12030652..12033411)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glutamate oxaloacetate transaminase 1 Neighboring gene uncharacterized protein Neighboring gene sister of tout-velu Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45993 Neighboring gene lambik

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Asparaginyl-tRNA Synthetase, a Novel Component of Hippo Signaling, Binds to Salvador and Enhances Yorkie-Mediated Tumorigenesis. Yeom E, et al. Front Cell Dev Biol, 2020. PMID 32117966, Free PMC Article
    2. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
    3. Quality-control mechanisms targeting translationally stalled and C-terminally extended poly(GR) associated with ALS/FTD. Li S, et al. Proc Natl Acad Sci U S A, 2020 Oct 6. PMID 32958650, Free PMC Article
    4. MISTERMINATE Mechanistically Links Mitochondrial Dysfunction with Proteostasis Failure. Wu Z, et al. Mol Cell, 2019 Aug 22. PMID 31378462, Free PMC Article
    5. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cysteine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cysteinyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cysteinyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cysteinyl-tRNA synthetase
    Names
    CG8431-PA
    CysRS-PA
    NP_611087.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16143147..16145906
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137243.3 → NP_611087.1  Cysteinyl-tRNA synthetase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611087.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KN90
      Related
      FBpp0086373
      Conserved Domains (2) summary
      cd00672
      Location:21 → 437
      CysRS_core; catalytic core domain of cysteinyl tRNA synthetase
      PTZ00399
      Location:2 → 737
      PTZ00399; cysteinyl-tRNA-synthetase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KN90.1 Q7KN90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools