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    smoc-1 Thyroglobulin type-1 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179609, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smoc-1
    Official Full Name
    Thyroglobulin type-1 domain-containing protein
    Primary source
    WormBase:WBGene00011437
    Locus tag
    CELE_T04F3.2
    See related
    AllianceGenome:WB:WBGene00011437
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium ion binding activity. Is expressed in hypodermis; intestine; pharyngeal-intestinal valve cell; and pharynx. Human ortholog(s) of this gene implicated in microphthalmia with limb anomalies. Orthologous to human SMOC1 (SPARC related modular calcium binding 1) and SMOC2 (SPARC related modular calcium binding 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See smoc-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (11757658..11758866)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans. DeGroot MS, et al. PLoS Biol, 2023 Aug. PMID 37590248, Free PMC Article
    2. Domain selection combined with improved cloning strategy for high throughput expression of higher eukaryotic proteins. Chen Y, et al. BMC Biotechnol, 2007 Jul 30. PMID 17663785, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans.
      Title: SMOC-1 interacts with both BMP and glypican to regulate BMP signaling in C. elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thyroglobulin type-1 domain-containing protein
    NP_505964.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      11757658..11758866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073563.4 → NP_505964.1  Thyroglobulin type-1 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505964.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22157
      Conserved Domains (3) summary
      cd00191
      Location:53 → 119
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      cd00252
      Location:138 → 238
      SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
      pfam13499
      Location:174 → 230
      EF-hand_7; EF-hand domain pair
    Nucleotide Protein
    Heading Accession and Version

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