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    kqt-3 Potassium voltage-gated channel subfamily KQT member 1 [ Caenorhabditis elegans ]

    Gene ID: 191699, updated on 9-Dec-2024

    Summary

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    Official Symbol
    kqt-3
    Official Full Name
    Potassium voltage-gated channel subfamily KQT member 1
    Primary source
    WormBase:WBGene00002235
    Locus tag
    CELE_Y54G9A.3
    See related
    AllianceGenome:WB:WBGene00002235
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables potassium channel activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and potassium ion transport. Predicted to be located in plasma membrane and synapse. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Is expressed in head neurons; intestine; and sensory neurons. Used to study Jervell-Lange Nielsen syndrome and long QT syndrome. Human ortholog(s) of this gene implicated in heart conduction disease (multiple); long QT syndrome (multiple); and type 2 diabetes mellitus. Orthologous to human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See kqt-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (13703873..13712898)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase;DNA-directed RNA polymerase subunit Neighboring gene ncRNA Neighboring gene Zinc transporter ZIP3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Resolving a contradiction: full gene deletion of kqt-3 by CRISPR does not lead to pharyngeal pumping defects. Bauer R, et al. MicroPubl Biol, 2019 Jul 25. PMID 32550436, Free PMC Article
    2. KCNQ-like potassium channels in Caenorhabditis elegans. Conserved properties and modulation. Wei AD, et al. J Biol Chem, 2005 Jun 3. PMID 15797864
    3. Cold acclimation via the KQT-2 potassium channel is modulated by oxygen in Caenorhabditis elegans. Okahata M, et al. Sci Adv, 2019 Feb. PMID 30775442, Free PMC Article
    4. Efficient isolation of targeted Caenorhabditis elegans deletion strains using highly thermostable restriction endonucleases and PCR. Wei A, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384612, Free PMC Article
    5. Intestinal Ca2+ wave dynamics in freely moving C. elegans coordinate execution of a rhythmic motor program. Nehrke K, et al. Am J Physiol Cell Physiol, 2008 Jan. PMID 17942636

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables outward rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion export across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Potassium voltage-gated channel subfamily KQT member 1
    NP_001254403.1
    • Confirmed by transcript evidence
    NP_001254404.1
    • Partially confirmed by transcript evidence
    NP_001254405.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      13703873..13712898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001267474.5 → NP_001254403.1  Potassium voltage-gated channel subfamily KQT member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254403.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XWG9
      Conserved Domains (3) summary
      pfam00520
      Location:108 → 313
      Ion_trans; Ion transport protein
      pfam03520
      Location:460 → 560
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:224 → 303
      Ion_trans_2; Ion channel

    2. NM_001267475.3 → NP_001254404.1  Potassium voltage-gated channel subfamily KQT member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254404.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7FAS2
      Conserved Domains (3) summary
      pfam00520
      Location:104 → 309
      Ion_trans; Ion transport protein
      pfam03520
      Location:456 → 556
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:220 → 299
      Ion_trans_2; Ion channel

    3. NM_001267476.3 → NP_001254405.1  Potassium voltage-gated channel subfamily KQT member 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001254405.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EE44
      Conserved Domains (3) summary
      pfam00520
      Location:67 → 272
      Ion_trans; Ion transport protein
      pfam03520
      Location:419 → 519
      KCNQ_channel; KCNQ voltage-gated potassium channel
      pfam07885
      Location:183 → 262
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version

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