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    T28B8.3 DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 189032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    T28B8.3
    Official Full Name
    DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00012114
    Locus tag
    CELE_T28B8.3
    See related
    AllianceGenome:WB:WBGene00012114
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in proteasomal ubiquitin-independent protein catabolic process. Predicted to be part of proteasome complex. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See T28B8.3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    22
    Sequence:
    Chromosome: I; NC_003279.8 (8151862..8159798)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene INSulin related Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Proteasome activator complex subunit 4 Neighboring gene ncRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptidase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables proteasome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasomal ubiquitin-independent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DUF3437 domain-containing protein;Proteasome activator complex subunit 4 C-terminal domain-containing protein
    NP_001040693.2
    • Partially confirmed by transcript evidence
    NP_001364595.1
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      8151862..8159798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001377608.2 → NP_001364595.1  DUF3437 domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91834
      Conserved Domains (3) summary
      sd00044
      Location:1707 → 1739
      HEAT; HEAT repeat [structural motif]
      pfam11919
      Location:1804 → 1888
      DUF3437; Domain of unknown function (DUF3437)
      pfam16507
      Location:325 → 860
      BLM10_mid; Proteasome-substrate-size regulator, mid region

    2. NM_001047228.2 → NP_001040693.2  Proteasome activator complex subunit 4 C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040693.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1ZXS9
      Conserved Domains (2) summary
      sd00044
      Location:257 → 289
      HEAT; HEAT repeat [structural motif]
      pfam11919
      Location:354 → 438
      DUF3437; Domain of unknown function (DUF3437)
    Nucleotide Protein
    Heading Accession and Version

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