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    Rgs19 regulator of G-protein signaling 19 [ Mus musculus (house mouse) ]

    Gene ID: 56470, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rgs19provided by MGI
    Official Full Name
    regulator of G-protein signaling 19provided by MGI
    Primary source
    MGI:MGI:1915153
    See related
    Ensembl:ENSMUSG00000002458 AllianceGenome:MGI:1915153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GAIP; 2610042F04Rik
    Summary
    Predicted to enable G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Predicted to be located in brush border and clathrin-coated vesicle. Is expressed in embryo; forelimb bud; palatal shelf epithelium; and primary palate epithelium. Orthologous to human RGS19 (regulator of G protein signaling 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in spleen adult (RPKM 53.3), thymus adult (RPKM 37.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rgs19 in Genome Data Viewer
    Location:
    2 H4; 2 103.72 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (181330212..181336330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (181688419..181694537, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene SRY (sex determining region Y)-box 18 Neighboring gene transcription elongation factor A (SII), 2 Neighboring gene LKAAEAR motif containing 1 (IKAAEAR murine motif) Neighboring gene STARR-positive B cell enhancer mm9_chr2:181441345-181441645 Neighboring gene opioid receptor-like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Critical role of Rgs19 in mouse embryonic stem cell proliferation and differentiation. Ji YR, et al. Differentiation, 2015 Jan-Feb. PMID 25766428
    2. Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19). Sangphech N, et al. Immunobiology, 2014 Sep. PMID 24775271, Free PMC Article
    3. Rgs19 regulates mouse palatal fusion by modulating cell proliferation and apoptosis in the MEE. Sohn WJ, et al. Mech Dev, 2012 Sep-Dec. PMID 22841956
    4. RGS19 enhances cell proliferation through its C-terminal PDZ motif. Tso PH, et al. Cell Signal, 2010 Nov. PMID 20599498
    5. Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19. Xie GX, et al. J Mol Biol, 2003 Jan 24. PMID 12507475

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings provide insight for the first time into the mechanisms involved in Rgs19 regulation of mouse ESC proliferation and differentiation.
      Title: Critical role of Rgs19 in mouse embryonic stem cell proliferation and differentiation.
    2. Notch signaling positively regulates phosphorylation of Akt, possibly via phosphorylation of RGS19
      Title: Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19).
    3. RGS19 and its partner Galpha-inhibiting activity polypeptide 3 (GNAI3) are involved in zVAD-, but not TNF-, induced cell death.
      Title: Regulator of G-protein signaling 19 (RGS19) and its partner Gα-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells.
    4. level of basal autophagy, autophagic induction, autophagic flux, autophagic degradation and the anti-autophagic action in macrophages that lacked Galphai3, AGS3, or RGS19; or had been treated with pertussis toxin, were similar to controls
      Title: Normal autophagic activity in macrophages from mice lacking Gαi3, AGS3, or RGS19.
    5. Rgs19 plays important roles in palatal fusion.
      Title: Rgs19 regulates mouse palatal fusion by modulating cell proliferation and apoptosis in the MEE.
    6. Regulator of G protein signaling 19 enhances cell proliferation through binding to GAIP-interacting protein C-terminus.
      Title: RGS19 enhances cell proliferation through its C-terminal PDZ motif.
    7. RGS19 influenced cardiac development and had negative effects on heart function.
      Title: Effects of regulator of G protein signaling 19 (RGS19) on heart development and function.
    8. Results suggest a complex role for RGS19 in regulating the ability of Wnt3a to signal to the level of beta-catenin and gene transcription.
      Title: RGS19 regulates Wnt-beta-catenin signaling through inactivation of Galpha(o).
    9. RGS19 prefers regulating ORL1 receptor signaling over other opioid receptors, and the N-terminal domain of RGS19 plays a crucial role in its receptor preference
      Title: N-terminally truncated variant of the mouse GAIP/RGS19 lacks selectivity of full-length GAIP/RGS19 protein in regulating ORL1 receptor signaling.
    10. gene structure and transcription regulation
      Title: Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 19
    Names
    G-alpha interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291205.1 → NP_001278134.1  regulator of G-protein signaling 19 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK042531, AL844529, BY540555
      Consensus CDS
      CCDS71223.1
      UniProtKB/TrEMBL
      B7ZCT1
      Related
      ENSMUSP00000104408.2, ENSMUST00000108778.8
      Conserved Domains (1) summary
      cd08745
      Location:114 → 231
      RGS_RGS19; Regulator of G protein signaling (RGS) domain found in the RGS19 protein

    2. NM_001291206.1 → NP_001278135.1  regulator of G-protein signaling 19 isoform b

      See identical proteins and their annotated locations for NP_001278135.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AK042531, AL845173, BG085760, BY540555
      Consensus CDS
      CCDS17220.1
      UniProtKB/Swiss-Prot
      Q99L50, Q9CX84
      UniProtKB/TrEMBL
      Q78NN4, Q8CGT5
      Related
      ENSMUSP00000104406.2, ENSMUST00000108776.8
      Conserved Domains (1) summary
      cl02565
      Location:87 → 204
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. NM_001291207.1 → NP_001278136.1  regulator of G-protein signaling 19 isoform c

      See identical proteins and their annotated locations for NP_001278136.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate 5' terminal exon and lacks an internal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
      Source sequence(s)
      AK019401, AK042531, AL845173, BU694737, BY540555
      Consensus CDS
      CCDS71222.1
      UniProtKB/TrEMBL
      Q8BFU4, Q8CGT5
      Related
      ENSMUSP00000104403.2, ENSMUST00000108772.8
      Conserved Domains (1) summary
      cl02565
      Location:65 → 182
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. NM_001291208.1 → NP_001278137.1  regulator of G-protein signaling 19 isoform c

      See identical proteins and their annotated locations for NP_001278137.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains an alternate 5' terminal exon and lacks an internal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a. Both variants 4 and 5 encode isoform c.
      Source sequence(s)
      AK042531, AL845173, BG085760, BY540555
      Consensus CDS
      CCDS71222.1
      UniProtKB/TrEMBL
      Q8BFU4, Q8CGT5
      Related
      ENSMUSP00000104402.2, ENSMUST00000108771.2
      Conserved Domains (1) summary
      cl02565
      Location:65 → 182
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    5. NM_001291209.1 → NP_001278138.1  regulator of G-protein signaling 19 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains alternate 5' and 3' terminal exons, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon and contains an alternate 3' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK019401, AK042531, AL845173, BY540555, BY549770, CF751080
      UniProtKB/TrEMBL
      B7ZCT0
      Related
      ENSMUSP00000104400.2, ENSMUST00000108769.8
      Conserved Domains (1) summary
      cl02565
      Location:52 → 157
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    6. NM_001291210.1 → NP_001278139.1  regulator of G-protein signaling 19 isoform e

      See identical proteins and their annotated locations for NP_001278139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains an alternate 5' terminal exon and lacks two internal exons, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AK019401, AK042531, AL845173, BY540555
      UniProtKB/Swiss-Prot
      Q9CX84
      UniProtKB/TrEMBL
      Q78NN4
      Conserved Domains (1) summary
      cl02565
      Location:1 → 110
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    7. NM_026446.4 → NP_080722.1  regulator of G-protein signaling 19 isoform b

      See identical proteins and their annotated locations for NP_080722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode isoform b.
      Source sequence(s)
      AK019401, AK042531, AL845173, BY540555
      Consensus CDS
      CCDS17220.1
      UniProtKB/Swiss-Prot
      Q99L50, Q9CX84
      UniProtKB/TrEMBL
      Q78NN4, Q8CGT5
      Related
      ENSMUSP00000002532.3, ENSMUST00000002532.9
      Conserved Domains (1) summary
      cl02565
      Location:87 → 204
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      181330212..181336330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251895.1 → XP_030107755.1  regulator of G-protein signaling 19 isoform X2

    2. XM_030251897.2 → XP_030107757.1  regulator of G-protein signaling 19 isoform X4

      UniProtKB/TrEMBL
      B7ZCT0
      Conserved Domains (1) summary
      cl02565
      Location:30 → 135
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. XM_030251896.1 → XP_030107756.1  regulator of G-protein signaling 19 isoform X3

      UniProtKB/TrEMBL
      B7ZCT0
      Conserved Domains (1) summary
      cl02565
      Location:52 → 157
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    4. XM_030251894.1 → XP_030107754.1  regulator of G-protein signaling 19 isoform X1

      UniProtKB/Swiss-Prot
      Q99L50, Q9CX84
      UniProtKB/TrEMBL
      Q78NN4, Q8CGT5
      Conserved Domains (1) summary
      cl02565
      Location:87 → 204
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CX84.1 GenPept UniProtKB/Swiss-Prot:Q9CX84

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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