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    Socs4 suppressor of cytokine signaling 4 [ Mus musculus (house mouse) ]

    Gene ID: 67296, updated on 27-Nov-2024

    Summary

    Official Symbol
    Socs4provided by MGI
    Official Full Name
    suppressor of cytokine signaling 4provided by MGI
    Primary source
    MGI:MGI:1914546
    See related
    Ensembl:ENSMUSG00000048379 AllianceGenome:MGI:1914546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Socs7; 3110032M18Rik; A730004F22Rik
    Summary
    Predicted to be involved in cytokine-mediated signaling pathway; negative regulation of epidermal growth factor-activated receptor activity; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Is expressed in ganglia; sensory organ; thymus primordium; and ventricular layer. Orthologous to human SOCS4 (suppressor of cytokine signaling 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 5.2), CNS E11.5 (RPKM 4.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Socs4 in Genome Data Viewer
    Location:
    14 C1; 14 24.6 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (47514377..47533559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (47276920..47296102)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene GTP cyclohydrolase 1 Neighboring gene poly(A) binding protein, cytoplasmic 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:47842732-47842946 Neighboring gene STARR-seq mESC enhancer starr_36567 Neighboring gene WD repeat and HMG-box DNA binding protein 1 Neighboring gene predicted gene, 24378 Neighboring gene STARR-seq mESC enhancer starr_36570 Neighboring gene mitogen-activated protein kinase 1 interacting protein 1-like Neighboring gene predicted gene, 35078 Neighboring gene STARR-seq mESC enhancer starr_36571 Neighboring gene STARR-seq mESC enhancer starr_36572 Neighboring gene predicted gene, 41147

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    suppressor of cytokine signaling 4
    Names
    SOCS-4
    SOCS-7
    suppressor of cytokine signaling 7
    suppressor of cytokine signalling 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080843.3NP_543119.2  suppressor of cytokine signaling 4

      See identical proteins and their annotated locations for NP_543119.2

      Status: VALIDATED

      Source sequence(s)
      AC156016, AK014115, AW046781, BG083279, CJ121925
      Consensus CDS
      CCDS26985.1
      UniProtKB/Swiss-Prot
      Q149F7, Q149F8, Q91ZA6
      Related
      ENSMUSP00000066031.5, ENSMUST00000065562.6
      Conserved Domains (3) summary
      cd10385
      Location:272372
      SH2_SOCS4; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03738
      Location:381436
      SOCS_SOCS4; SOCS (suppressors of cytokine signaling) box of SOCS4-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the ...
      pfam12610
      Location:58106
      SOCS; Suppressor of cytokine signalling

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      47514377..47533559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)