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    cag cag [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36157, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cagprovided by FlyBase
    Official Full Name
    cagprovided by FlyBase
    Primary source
    FLYBASE:FBgn0017414
    Locus tag
    Dmel_CG12346
    See related
    AllianceGenome:FB:FBgn0017414
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12346; Dmel\CG12346
    Summary
    Predicted to enable DNA binding activity. Predicted to be active in nucleus. Is expressed in organism. Human ortholog(s) of this gene implicated in inner ear disease and primary biliary cholangitis. Orthologous to human CENPB (centromere protein B); TIGD4 (tigger transposable element derived 4); and TIGD6 (tigger transposable element derived 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cag in Genome Data Viewer
    Location:
    47C5-47C6; 2-63 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10893034..10894414, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6780539..6781919, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Hydroxyacid oxidase Neighboring gene uncharacterized protein Neighboring gene mir-1008 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene NADH dehydrogenase (ubiquinone) B14 subunit Neighboring gene RNA polymerase II, I and III subunit E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pogo-like transposases have been repeatedly domesticated into CENP-B-related proteins. Mateo L, et al. Genome Biol Evol, 2014 Jul 24. PMID 25062917, Free PMC Article
    2. The bHLH transcription factor hand is required for proper wing heart formation in Drosophila. Tögel M, et al. Dev Biol, 2013 Sep 15. PMID 23747982
    3. Muscleblind, BSF and TBPH are mislocalized in the muscle sarcomere of a Drosophila myotonic dystrophy model. Llamusi B, et al. Dis Model Mech, 2013 Jan. PMID 23118342, Free PMC Article
    4. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article
    5. Next-generation large-scale binary protein interaction network for Drosophila melanogaster. Tang HW, et al. Nat Commun, 2023 Apr 15. PMID 37061542, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cag
    Names
    CG12346-PA
    CG12346-PB
    cag-PA
    cag-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10893034..10894414 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057859.4 → NP_477207.1  cag, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91673, Q7JR24
      Related
      FBpp0087334
      Conserved Domains (2) summary
      smart00674
      Location:78 → 141
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam04218
      Location:7 → 60
      CENP-B_N; CENP-B N-terminal DNA-binding domain

    2. NM_001273947.1 → NP_001260876.1  cag, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260876.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      P91673, Q7JR24
      Conserved Domains (2) summary
      smart00674
      Location:78 → 141
      CENPB; Putative DNA-binding domain in centromere protein B, mouse jerky and transposases
      pfam04218
      Location:7 → 60
      CENP-B_N; CENP-B N-terminal DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P91673 P91673
    Q7JR24 Q7JR24

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