Zfp189 zinc finger protein 189 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp189provided by MGI
Official Full Name: zinc finger protein 189provided by MGI
Primary source: MGI:MGI:2444707
See related: Ensembl:ENSMUSG00000039634 AllianceGenome:MGI:2444707
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C430015I23Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; central nervous system; and eye. Orthologous to human ZNF189 (zinc finger protein 189). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.7), CNS E14 (RPKM 2.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.55 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (49521176..49531558)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (49521176..49531558)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis.
Title: Zinc finger protein 189 promotes the differentiation of lamina propria T helper 17.1 cells in dextran sulfate sodium-induced colitis.
CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use.
Title: CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use.
Zfp189 in prefrontal cortical neurons...promotes behavioral resilience
Title: Stress resilience is promoted by a Zfp189-driven transcriptional network in prefrontal cortex.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: zinc finger protein 189

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289901.1 → NP_001276830.1 zinc finger protein 189

See identical proteins and their annotated locations for NP_001276830.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK049475, AK051265, BY085925, BY420591

Consensus CDS

CCDS18175.1

UniProtKB/TrEMBL

Q8BKP2

Related

ENSMUSP00000036663.7, ENSMUST00000042964.13

Conserved Domains (4) summary

cd07765
Location:12 → 39

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

COG5048
Location:116 → 506

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:328 → 348

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:368 → 393

zf-H2C2_2; Zinc-finger double domain
NM_145547.3 → NP_663522.2 zinc finger protein 189

See identical proteins and their annotated locations for NP_663522.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK049475, AK051265, BY085925, BY420591

Consensus CDS

CCDS18175.1

UniProtKB/TrEMBL

Q8BKP2

Related

ENSMUSP00000103324.2, ENSMUST00000107696.2

Conserved Domains (4) summary

cd07765
Location:12 → 39

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

COG5048
Location:116 → 506

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:328 → 348

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:368 → 393

zf-H2C2_2; Zinc-finger double domain