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    Fam76a family with sequence similarity 76, member A [ Mus musculus (house mouse) ]

    Gene ID: 230789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam76aprovided by MGI
    Official Full Name
    family with sequence similarity 76, member Aprovided by MGI
    Primary source
    MGI:MGI:2385211
    See related
    Ensembl:ENSMUSG00000028878 AllianceGenome:MGI:2385211
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Is expressed in embryo. Orthologous to human FAM76A (family with sequence similarity 76 member A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 26.9), bladder adult (RPKM 9.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam76a in Genome Data Viewer
    Location:
    4 D2.3; 4 66.01 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132626524..132649849, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132899213..132922760, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene syntaxin 12 Neighboring gene prostaglandin-endoperoxide synthase 2 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2716 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132500014-132500167 Neighboring gene STARR-positive B cell enhancer ABC_E9242 Neighboring gene predicted gene, 36518 Neighboring gene STARR-seq mESC enhancer starr_11587 Neighboring gene STARR-seq mESC enhancer starr_11589 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132531847-132532036 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:132533610-132533847 Neighboring gene FGR proto-oncogene, Src family tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_11591

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article
    2. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC11672

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein FAM76A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163792.2 → NP_001157264.1  protein FAM76A isoform B

      Status: VALIDATED

      Source sequence(s)
      AL671190
      Consensus CDS
      CCDS51320.1
      UniProtKB/Swiss-Prot
      Q922G2
      Related
      ENSMUSP00000095468.4, ENSMUST00000097856.10
      Conserved Domains (1) summary
      pfam16046
      Location:4 → 263
      FAM76; FAM76 protein

    2. NM_001426077.1 → NP_001413006.1  protein FAM76A isoform C

      Status: VALIDATED

      Source sequence(s)
      AL671190

    3. NM_001426078.1 → NP_001413007.1  protein FAM76A isoform D

      Status: VALIDATED

      Source sequence(s)
      AL671190

    4. NM_001426079.1 → NP_001413008.1  protein FAM76A isoform E

      Status: VALIDATED

      Source sequence(s)
      AL671190

    5. NM_145553.3 → NP_663528.1  protein FAM76A isoform A

      See identical proteins and their annotated locations for NP_663528.1

      Status: VALIDATED

      Source sequence(s)
      AL671190
      Consensus CDS
      CCDS18738.1
      UniProtKB/Swiss-Prot
      A2ADS2, Q3U3U8, Q3V3N2, Q922G2
      Related
      ENSMUSP00000030696.5, ENSMUST00000030696.11
      Conserved Domains (1) summary
      pfam16046
      Location:4 → 292
      FAM76; FAM76 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132626524..132649849 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q922G2.1 GenPept UniProtKB/Swiss-Prot:Q922G2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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