U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    nes nessy [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40093, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    nesprovided by FlyBase
    Official Full Name
    nessyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026630
    Locus tag
    Dmel_CG9655
    See related
    AllianceGenome:FB:FBgn0026630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9655; Dmel\CG9655; Nes
    Summary
    Enables lysophospholipid acyltransferase activity. Involved in several processes, including germ cell migration; lipid modification; and sperm individualization. Located in membrane. Is expressed in several structures, including adult head; cephalic furrow; germ layer; germline cell; and mesectoderm anlage. Orthologous to human LPCAT3 (lysophosphatidylcholine acyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See nes in Genome Data Viewer
    Location:
    76A3-76A3; 3-45 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19257282..19260679, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19250382..19253779, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L21 Neighboring gene reptin Neighboring gene antisense RNA:CR45210 Neighboring gene Blocked early in transport 1 Neighboring gene Max Neighboring gene uncharacterized protein Neighboring gene Methyltransferase like 5 Neighboring gene uncharacterized protein Neighboring gene Aldehyde dehydrogenase 7 family member A1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. nessy, an evolutionary conserved gene controlled by Hox proteins during Drosophila embryogenesis. Maurel-Zaffran C, et al. Mech Dev, 1999 Aug. PMID 10446276
    2. Drosophila lysophospholipid acyltransferases are specifically required for germ cell development. Steinhauer J, et al. Mol Biol Cell, 2009 Dec. PMID 19864461, Free PMC Article
    3. Drosophila spermatid individualization is sensitive to temperature and fatty acid metabolism. Ben-David G, et al. Spermatogenesis, 2015 Jan-Apr. PMID 26413411, Free PMC Article
    4. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide. Wang W, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2019 Feb. PMID 30521938
    5. Drosophila Pif1A is essential for spermatogenesis and is the homolog of human CCDC157, a gene associated with idiopathic NOA. Yuan X, et al. Cell Death Dis, 2019 Feb 11. PMID 30741974, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 1-acylglycerophosphocholine O-acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophospholipid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in germ cell migration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in lipid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylcholine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine acyl-chain remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in plasma membrane organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sperm individualization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    nessy
    Names
    CG9655-PA
    CG9655-PB
    CG9655-PC
    nes-PA
    nes-PB
    nes-PC
    NP_524157.2
    NP_730390.1
    NP_788527.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19257282..19260679 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079433.3 → NP_524157.2  nessy, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524157.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V238, Q9VVX5, Q9XYV9
      Related
      FBpp0074786
      Conserved Domains (1) summary
      pfam03062
      Location:114 → 421
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    2. NM_176349.2 → NP_788527.1  nessy, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788527.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V238, Q9VVX5, Q9XYV9
      Related
      FBpp0074788
      Conserved Domains (1) summary
      pfam03062
      Location:114 → 421
      MBOAT; MBOAT, membrane-bound O-acyltransferase family

    3. NM_168788.3 → NP_730390.1  nessy, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730390.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V238, Q9VVX5, Q9XYV9
      Related
      FBpp0074787
      Conserved Domains (1) summary
      pfam03062
      Location:114 → 421
      MBOAT; MBOAT, membrane-bound O-acyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVX5.1 Q9VVX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous