Cnksr3 Cnksr family member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnksr3provided by MGI
Official Full Name: Cnksr family member 3provided by MGI
Primary source: MGI:MGI:2674130
See related: Ensembl:ENSMUSG00000015202 AllianceGenome:MGI:2674130
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Magi1; 6820402C05
Summary: Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of peptidyl-serine phosphorylation; and positive regulation of sodium ion transport. Acts upstream of or within positive regulation of sodium ion transmembrane transporter activity. Predicted to be located in apical plasma membrane and cytoplasm. Is expressed in dentate gyrus subgranular zone. Orthologous to human CNKSR3 (CNKSR family member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 8.5), bladder adult (RPKM 8.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 A1; 10 1.85 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (7069061..7162237, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (7119061..7212237, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis.
Title: Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex.
CNKSR3, a homologue of scaffold proteins involved in MAPK pathway regulation, is a direct target of MR and is required for the maintenance of transepithelial sodium transport in the kidney.
Title: Cnksr3 is a direct mineralocorticoid receptor target gene and plays a key role in the regulation of the epithelial sodium channel.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of sodium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: connector enhancer of kinase suppressor of ras 3

Names: CNK homolog protein 3; CNK3; connector enhancer of KSR 3; maguin-like protein; membrane associated guanylate kinase interacting protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172546.2 → NP_766134.1 connector enhancer of kinase suppressor of ras 3

See identical proteins and their annotated locations for NP_766134.1

Status: PROVISIONAL

Source sequence(s)

AK033015

Consensus CDS

CCDS56690.1

UniProtKB/Swiss-Prot

Q3UDS2, Q8BMA3, Q8K2K0

Related

ENSMUSP00000015346.6, ENSMUST00000015346.12

Conserved Domains (5) summary

cd09511
Location:4 → 72

SAM_CNK1,2,3-suppressor; SAM domain of CNK1,2,3-suppressor subfamily

smart00454
Location:4 → 69

SAM; Sterile alpha motif

pfam06663
Location:334 → 545

DUF1170; Protein of unknown function (DUF1170)

pfam10534
Location:80 → 171

CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

cl00117
Location:221 → 305

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

7069061..7162237 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155726.1 → XP_036011619.1 connector enhancer of kinase suppressor of ras 3 isoform X1

Conserved Domains (3) summary

pfam06663
Location:252 → 465

DUF1170; Protein of unknown function (DUF1170)

pfam10534
Location:1 → 91

CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

cl00117
Location:141 → 225

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
XM_030244998.2 → XP_030100858.1 connector enhancer of kinase suppressor of ras 3 isoform X1

Conserved Domains (3) summary

pfam06663
Location:252 → 465

DUF1170; Protein of unknown function (DUF1170)

pfam10534
Location:1 → 91

CRIC_ras_sig; Connector enhancer of kinase suppressor of ras

cl00117
Location:141 → 225

PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...