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    Eif2b2 eukaryotic translation initiation factor 2B, subunit 2 beta [ Mus musculus (house mouse) ]

    Gene ID: 217715, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eif2b2provided by MGI
    Official Full Name
    eukaryotic translation initiation factor 2B, subunit 2 betaprovided by MGI
    Primary source
    MGI:MGI:2145118
    See related
    Ensembl:ENSMUSG00000004788 AllianceGenome:MGI:2145118
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EIF2B; EIF-2Bbeta
    Summary
    This gene encodes the beta subunit of eukaryotic initiation factor-2B (EIF2B). EIF2B is involved in protein synthesis and exchanges GDP and GTP for its activation and deactivation. Mutations in the human gene are associated with ovarioleukodystrophy and leukoencephalopathy with vanishing white matter. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 35.6), thymus adult (RPKM 34.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Eif2b2 in Genome Data Viewer
    Location:
    12 D1; 12 39.6 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85266255..85273402)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85219481..85226628)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene placental growth factor Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86533825-86534109 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1858 Neighboring gene mutL homolog 3 Neighboring gene microRNA 6938 Neighboring gene 40S ribosomal protein S25 pseudogene

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to translation initiation factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in T cell receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in central nervous system development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in central nervous system development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoplasmic translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in oligodendrocyte development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oligodendrocyte development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in ovarian follicle development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ovarian follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 2B complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 2B complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of eukaryotic translation initiation factor 2B complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in glycinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    translation initiation factor eIF2B subunit beta
    Names
    eIF-2B GDP-GTP exchange factor subunit beta
    eIF2B GDP-GTP exchange factor subunit beta
    translation initiation factor eIF-2B subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145445.4NP_663420.1  translation initiation factor eIF2B subunit beta

      See identical proteins and their annotated locations for NP_663420.1

      Status: REVIEWED

      Source sequence(s)
      AC159237, AK049731
      Consensus CDS
      CCDS26053.1
      UniProtKB/Swiss-Prot
      Q99LD9
      UniProtKB/TrEMBL
      Q8BK57
      Related
      ENSMUSP00000004910.6, ENSMUST00000004910.12
      Conserved Domains (1) summary
      pfam01008
      Location:28333
      IF-2B; Initiation factor 2 subunit family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      85266255..85273402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)