U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mio missing oocyte [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33399, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    mioprovided by FlyBase
    Official Full Name
    missing oocyteprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031399
    Locus tag
    Dmel_CG7074
    See related
    AllianceGenome:FB:FBgn0031399
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15384; CG7074; Dmel\CG7074; FBtr0077835; GATOR2; Mio; Sea4; SEA4
    Summary
    Involved in several processes, including oogenesis; positive regulation of TORC1 signaling; and regulation of autophagy. Located in autolysosome and female germ cell nucleus. Part of GATOR2 complex. Is expressed in adult head; germarium region 2a; oocyte; and ovary. Orthologous to human MIOS (meiosis regulator for oocyte development). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See mio in Genome Data Viewer
    Location:
    22D4-22D4; 2-5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2217290..2220625)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2217290..2220625)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene daedalus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene papi Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis. Senger S, et al. Development, 2011 May. PMID 21521741, Free PMC Article
    2. Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila. Gu X, et al. Nature, 2022 Aug. PMID 35859173, Free PMC Article
    3. TORC1 regulators Iml1/GATOR1 and GATOR2 control meiotic entry and oocyte development in Drosophila. Wei Y, et al. Proc Natl Acad Sci U S A, 2014 Dec 30. PMID 25512509, Free PMC Article
    4. Insulator-based loops mediate the spreading of H3K27me3 over distant micro-domains repressing euchromatin genes. Heurteau A, et al. Genome Biol, 2020 Aug 3. PMID 32746892, Free PMC Article
    5. FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila. Zhou Y, et al. Cell Death Dis, 2021 Jun 2. PMID 34078879, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Like mio, seh1 has a crucial germline function during oogenesis. In both mio and seh1 mutant ovaries, a fraction of oocytes fail to maintain the meiotic cycle and develop as pseudo-nurse cells.
      Title: The nucleoporin Seh1 forms a complex with Mio and serves an essential tissue-specific function in Drosophila oogenesis.
    2. product of the missing oocyte gene acts in the oocyte nucleus to facilitate the execution of the unique cell cycle and developmental programs that produce the mature haploid gamete
      Title: missing oocyte encodes a highly conserved nuclear protein required for the maintenance of the meiotic cycle and oocyte identity in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in cellular response to amino acid starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to amino acid starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germarium-derived egg chamber formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oocyte fate determination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GATOR2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Seh1-associated complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in autolysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in female germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    missing oocyte
    Names
    CG7074-PA
    mio-PA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2217290..2220625
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_134812.3 → NP_608656.1  missing oocyte [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608656.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95RC2, Q9VQ89
      Related
      FBpp0077507
      Conserved Domains (4) summary
      COG2319
      Location:65 → 266
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:8 → 44
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:60 → 266
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl24077
      Location:741 → 852
      Zn_ribbon_17; Zinc-ribbon, C4HC2 type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQ89.2 Q9VQ89

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools