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    smog smog [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33690, updated on 9-Dec-2024

    Summary

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    Official Symbol
    smogprovided by FlyBase
    Official Full Name
    smogprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051660
    Locus tag
    Dmel_CG31660
    See related
    AllianceGenome:FB:FBgn0051660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0170980.181; anon-WO0170980.182; CG11923; CG11925; CG31660; Dmel\CG31660; pog; Smog
    Summary
    Enables G protein-coupled receptor activity. Involved in several processes, including gastrulation; mesectoderm development; and positive regulation of antibacterial peptide biosynthetic process. Is active in plasma membrane. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See smog in Genome Data Viewer
    Location:
    25B1-25B1; 2-14 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4852864..4876792)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4852864..4876792)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S2 Neighboring gene Monensin sensitivity 1 Neighboring gene Chorion factor 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcriptional Pre-patterning of Drosophila Gastrulation. Lim B, et al. Curr Biol, 2017 Jan 23. PMID 28089518, Free PMC Article
    2. FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the Drosophila nervous system. Shweta K, et al. G3 (Bethesda), 2021 Mar 16. PMID 33729500, Free PMC Article
    3. Multifunctional role of GPCR signaling in epithelial tube formation. Vishwakarma V, et al. Development, 2022 Aug 1. PMID 35876688
    4. Dedicated photoreceptor pathways in Drosophila larvae mediate navigation by processing either spatial or temporal cues. Humberg TH, et al. Nat Commun, 2018 Mar 28. PMID 29593252, Free PMC Article
    5. Quantitative Control of GPCR Organization and Signaling by Endocytosis in Epithelial Morphogenesis. Jha A, et al. Curr Biol, 2018 May 21. PMID 29731302, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the Drosophila nervous system.
      Title: FGFR/Heartless and Smog interact synergistically to negatively regulate Fog mediated G-protein coupled receptor signaling in the Drosophila nervous system.
    2. The G protein-coupled receptor Smog activity is concentrated on two different apical plasma membrane compartments, i.e., the surface and plasma membrane invaginations.
      Title: Quantitative Control of GPCR Organization and Signaling by Endocytosis in Epithelial Morphogenesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in apical constriction involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in convergent extension involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of cytoskeleton polarity involved in gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of antibacterial peptide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gastrulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of myosin II filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    smog
    Names
    CG31660-PB
    CG31660-PC
    CG31660-PD
    CG31660-PE
    CG31660-PF
    poor gastrulation
    smog-PB
    smog-PC
    smog-PD
    smog-PE
    smog-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4852864..4876792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273127.1 → NP_001260056.1  smog, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260056.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PEK9
      Conserved Domains (1) summary
      pfam00003
      Location:542 → 776
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    2. NM_001258953.2 → NP_001245882.1  smog, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245882.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDF0
      Conserved Domains (1) summary
      pfam00003
      Location:542 → 776
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    3. NM_001258952.2 → NP_001245881.1  smog, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245881.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9ND25
      Conserved Domains (1) summary
      pfam00003
      Location:542 → 776
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    4. NM_164600.4 → NP_723019.2  smog, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723019.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VR40
      Conserved Domains (1) summary
      pfam00003
      Location:542 → 776
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    5. NM_001014465.3 → NP_001014465.1  smog, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014465.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E18
      Conserved Domains (1) summary
      pfam00003
      Location:542 → 776
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9ND25 M9ND25
    M9NDF0 M9NDF0
    M9PEK9 M9PEK9
    Q59E18 Q59E18
    Q86P57 Q86P57
    Q9VR40 Q9VR40

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