G0s2 G0/G1 switch gene 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: G0s2provided by MGI
Official Full Name: G0/G1 switch gene 2provided by MGI
Primary source: MGI:MGI:1316737
See related: Ensembl:ENSMUSG00000009633 AllianceGenome:MGI:1316737
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Involved in positive regulation of cold-induced thermogenesis. Predicted to be active in mitochondrion. Is expressed in liver and trunk mesenchyme. Orthologous to human G0S2 (G0/G1 switch 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 223.8), liver E18 (RPKM 211.3) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 97.69 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (192954468..192955496, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (193272160..193273188, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of G0S2 on insulin sensitivity: A proteomic analysis in a G0S2-overexpressed high-fat diet mouse model.
Title: The effect of G0S2 on insulin sensitivity: A proteomic analysis in a G0S2-overexpressed high-fat diet mouse model.
G0S2 is regulated by the PERK-eIF2alpha-ATF4 branch of the UPR and mediates ER stress-induced hepatic steatosis.
Title: Activation of G0/G1 switch gene 2 by endoplasmic reticulum stress enhances hepatic steatosis.
ER+ breast cancer cells with restored G0S2 expression had a relative increased sensitivity to tamoxifen
Title: G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer.
G0S2 protein but not mRNA levels were reduced in the adipose tissue of ATGL-deficient mice, corroborating the involvement of ATGL in the stabilization of G0S2
Title: Regulation of G0/G1 Switch Gene 2 (G0S2) Protein Ubiquitination and Stability by Triglyceride Accumulation and ATGL Interaction.
G0S2 silencing mediates MYC-induced oncogenesis in other malignancies
Title: G0S2 Suppresses Oncogenic Transformation by Repressing a MYC-Regulated Transcriptional Program.
G0S2 expression in naive CD8(+) T cells decreased immediately after T-cell receptor activation downstream of various signal transduction pathways. G0S2 inhibits energy production by oxidative phosphorylation to fine-tune proliferation in homeostasis.
Title: G0S2 modulates homeostatic proliferation of naïve CD8⁺ T cells and inhibits oxidative phosphorylation in mitochondria.
findings do not rule out the possibility that G0S2 may be playing a role in other forms of leukemia, but clearly show that the commonly used Emu-Myc transgenic is not the correct model to conduct studies on G0s2
Title: Deletion of the putative tumor suppressor gene, G0s2, does not affect progression of Eμ-Myc driven lymphomas in mice.
G0s2 is a physiological regulator of adiposity and energy metabolism and is a potential target in the treatment of obesity and insulin resistance.
Title: Deletion of the gene encoding G0/G 1 switch protein 2 (G0s2) alleviates high-fat-diet-induced weight gain and insulin resistance, and promotes browning of white adipose tissue in mice.
Proteasomal degradation of PPAR-gamma and the reduction of g0s2 content are permissive for prolonged TNF-alpha induced lipolysis.
Title: TNF-α reduces g0s2 expression and stimulates lipolysis through PPAR-γ inhibition in 3T3-L1 adipocytes.
G0s2 has an important role in adipogenesis and accumulation of triacylglycerol.
Title: G0/G1 switch gene 2 has a critical role in adipocyte differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136018 (e-PCR)
- UniSTS:210014

AV006465 (e-PCR)
- UniSTS:178556

NoName (e-PCR)
- UniSTS:492227

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of extrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: G0/G1 switch protein 2

Names: G0S2-like protein; putative lymphocyte G0/G1 switch protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.