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    Rac1 Rac family small GTPase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19353, updated on 10-Dec-2024

    Summary

    Official Symbol
    Rac1provided by MGI
    Official Full Name
    Rac family small GTPase 1provided by MGI
    Primary source
    MGI:MGI:97845
    See related
    Ensembl:ENSMUSG00000001847 AllianceGenome:MGI:97845
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Ertd559e
    Summary
    Enables G protein activity; GTP binding activity; and GTP-dependent protein binding activity. Involved in several processes, including nervous system development; positive regulation of protein localization; and regulation of cell migration. Acts upstream of or within several processes, including actin filament polymerization; generation of neurons; and regulation of intracellular signal transduction. Located in several cellular components, including kinocilium; pericentriolar material; and ruffle membrane. Is active in glutamatergic synapse; synaptic membrane; and synaptic vesicle membrane. Is expressed in several structures, including early conceptus; eye; genitourinary system; lower leg bone; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 163.9), small intestine adult (RPKM 137.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rac1 in Genome Data Viewer
    Location:
    5 G2; 5 82.22 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143491236..143513786, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143505481..143528031, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9497 Neighboring gene diacylglycerol lipase, beta Neighboring gene STARR-seq mESC enhancer starr_14793 Neighboring gene small integral membrane protein 10 like 3 Neighboring gene family with sequence similarity 220, member A Neighboring gene predicted gene, 54311

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding  
    enables G protein activity PubMed 
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTP binding PubMed 
    enables GTP-dependent protein binding PubMed 
    enables GTPase activity  
    enables GTPase activity PubMed 
    enables GTPase activity PubMed 
    enables Rho GDP-dissociation inhibitor binding  
    enables Rho GDP-dissociation inhibitor binding  
    enables enzyme binding  
    enables histone deacetylase binding  
    enables membrane scission GTPase motor activity  
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein kinase binding  
    enables protein-containing complex binding  
    enables small GTPase binding  
    enables thioesterase binding  
    Items 1 - 25 of 119
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
    involved_in Rac protein signal transduction  
    involved_in Rac protein signal transduction PubMed 
    involved_in Rac protein signal transduction  
    acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    involved_in actin filament organization  
    involved_in actin filament organization  
    acts_upstream_of_or_within actin filament polymerization PubMed 
    acts_upstream_of_or_within anatomical structure arrangement PubMed 
    acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process PubMed 
    acts_upstream_of_or_within auditory receptor cell morphogenesis PubMed 
    acts_upstream_of_or_within axon guidance PubMed 
    involved_in bone resorption  
    acts_upstream_of_or_within cell adhesion PubMed 
    involved_in cell chemotaxis  
    acts_upstream_of_or_within cell migration PubMed 
    involved_in cell migration  
    involved_in cell motility  
    involved_in cell motility  
    involved_in cell projection assembly  
    acts_upstream_of_or_within cell-cell junction organization PubMed 
    involved_in cellular response to mechanical stimulus  
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron development PubMed 
    acts_upstream_of_or_within cerebral cortex radially oriented cell migration PubMed 
    involved_in chemotaxis  
    acts_upstream_of_or_within cochlea morphogenesis PubMed 
    involved_in cortical cytoskeleton organization  
    acts_upstream_of_or_within cytoskeleton organization PubMed 
    acts_upstream_of_or_within dendrite development PubMed 
    acts_upstream_of_or_within dendrite morphogenesis PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation PubMed 
    acts_upstream_of_or_within embryonic olfactory bulb interneuron precursor migration PubMed 
    acts_upstream_of_or_within endocytosis PubMed 
    involved_in engulfment of apoptotic cell PubMed 
    involved_in enzyme-linked receptor protein signaling pathway PubMed 
    acts_upstream_of_or_within epithelial cell morphogenesis PubMed 
    acts_upstream_of_or_within erythrocyte enucleation PubMed 
    involved_in establishment or maintenance of cell polarity  
    involved_in forebrain development PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue PubMed 
    acts_upstream_of_or_within hyperosmotic response PubMed 
    acts_upstream_of_or_within interneuron migration PubMed 
    acts_upstream_of_or_within lamellipodium assembly PubMed 
    involved_in lamellipodium assembly  
    acts_upstream_of_or_within lamellipodium assembly PubMed 
    involved_in localization within membrane  
    involved_in mast cell chemotaxis  
    involved_in midbrain dopaminergic neuron differentiation PubMed 
    involved_in motor neuron axon guidance  
    involved_in negative regulation of fibroblast migration  
    involved_in negative regulation of interleukin-23 production  
    acts_upstream_of_or_within neuron migration PubMed 
    involved_in neuron migration PubMed 
    involved_in neuron projection morphogenesis PubMed 
    involved_in non-canonical Wnt signaling pathway PubMed 
    involved_in phagocytosis, engulfment PubMed 
    involved_in positive regulation of DNA replication  
    acts_upstream_of_or_within positive regulation of actin filament polymerization PubMed 
    involved_in positive regulation of bicellular tight junction assembly  
    involved_in positive regulation of cell-substrate adhesion  
    acts_upstream_of_or_within positive regulation of dendritic spine development PubMed 
    acts_upstream_of_or_within positive regulation of dendritic spine development PubMed 
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of filopodium assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus  
    acts_upstream_of_or_within positive regulation of lamellipodium assembly PubMed 
    involved_in positive regulation of lamellipodium assembly  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of neutrophil chemotaxis PubMed 
    involved_in positive regulation of neutrophil chemotaxis  
    involved_in positive regulation of ovarian follicle development PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering PubMed 
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in postsynaptic actin cytoskeleton organization  
    acts_upstream_of_or_within protein localization to plasma membrane PubMed 
    acts_upstream_of_or_within regulation of ERK5 cascade PubMed 
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of cell adhesion involved in heart morphogenesis PubMed 
    involved_in regulation of cell migration  
    acts_upstream_of_or_within regulation of cell morphogenesis PubMed 
    involved_in regulation of cell shape  
    involved_in regulation of cell size  
    involved_in regulation of fibroblast migration PubMed 
    involved_in regulation of lamellipodium assembly  
    acts_upstream_of_or_within regulation of neuron maturation PubMed 
    acts_upstream_of_or_within regulation of neuron migration PubMed 
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity PubMed 
    acts_upstream_of_or_within regulation of neuronal synaptic plasticity PubMed 
    involved_in regulation of neutrophil migration  
    involved_in regulation of nitric oxide biosynthetic process  
    involved_in regulation of postsynapse assembly PubMed 
    involved_in regulation of postsynapse assembly PubMed 
    involved_in regulation of receptor signaling pathway via JAK-STAT PubMed 
    involved_in regulation of respiratory burst  
    involved_in regulation of stress fiber assembly  
    involved_in regulation of synaptic vesicle endocytosis PubMed 
    involved_in regulation of synaptic vesicle endocytosis PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in ruffle assembly PubMed 
    involved_in ruffle assembly  
    acts_upstream_of_or_within ruffle organization PubMed 
    involved_in semaphorin-plexin signaling pathway  
    involved_in semaphorin-plexin signaling pathway  
    acts_upstream_of_or_within small GTPase-mediated signal transduction PubMed 
    involved_in small GTPase-mediated signal transduction  
    involved_in sphingosine-1-phosphate receptor signaling pathway  
    acts_upstream_of_or_within substrate adhesion-dependent cell spreading PubMed 
    involved_in substrate adhesion-dependent cell spreading PubMed 
    involved_in substrate adhesion-dependent cell spreading  
    acts_upstream_of_or_within synaptic transmission, GABAergic PubMed 
    Items 1 - 25 of 119
    Items 1 - 20 of 42
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    located_in Golgi membrane  
    colocalizes_with actin filament  
    located_in cell cortex  
    located_in cell projection PubMed 
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytoplasmic ribonucleoprotein granule  
    is_active_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle PubMed 
    is_active_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite  
    is_active_in dendritic spine  
    located_in dendritic spine  
    located_in early endosome membrane PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in kinocilium PubMed 
    located_in lamellipodium PubMed 
    located_in lamellipodium  
    located_in melanosome  
    located_in membrane PubMed 
    located_in membrane  
    located_in nucleus PubMed 
    located_in nucleus  
    located_in pericentriolar material PubMed 
    located_in phagocytic cup PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse  
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    located_in recycling endosome membrane  
    located_in ruffle membrane PubMed 
    located_in ruffle membrane  
    is_active_in synaptic vesicle membrane PubMed 
    located_in trans-Golgi network  
    Items 1 - 20 of 42

    General protein information

    Preferred Names
    ras-related C3 botulinum toxin substrate 1
    Names
    RAS-related C3 botulinum substrate 1
    p21-Rac1
    NP_001334459.1
    NP_033033.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347530.1NP_001334459.1  ras-related C3 botulinum toxin substrate 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC217112
      Consensus CDS
      CCDS84993.1
      UniProtKB/TrEMBL
      Q3TLP8, Q8BPG5, Q9D859
      Related
      ENSMUSP00000098058.4, ENSMUST00000100489.4
    2. NM_009007.2NP_033033.1  ras-related C3 botulinum toxin substrate 1 isoform 2

      See identical proteins and their annotated locations for NP_033033.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BQ444803, CO425367, CX242948, CX566679
      Consensus CDS
      CCDS19843.1
      UniProtKB/Swiss-Prot
      P63001
      UniProtKB/TrEMBL
      K7Q7T7, Q8BPG5, Q9D859
      Related
      ENSMUSP00000079380.8, ENSMUST00000080537.14
      Conserved Domains (1) summary
      cd01871
      Location:3176
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143491236..143513786 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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