sktl skittles [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: sktlprovided by FlyBase
Official Full Name: skittlesprovided by FlyBase
Primary source: FLYBASE:FBgn0016984
Locus tag: Dmel_CG9985
See related: AllianceGenome:FB:FBgn0016984
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 25/17; CG9985; Dmel\CG9985; fam; l(2)05475; l(2)k12405; PIP5-kinase; PIP5K; PIP5K 57B6; ski; Sktl; SKTL
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Involved in several processes, including basement membrane organization; endosome organization; and germ cell development. Located in cell cortex; male germline ring canal; and plasma membrane. Colocalizes with apical plasma membrane. Is expressed in several structures, including anlage in statu nascendi; epithelial furrow; germline cell; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to several human genes including PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (20827282..20836028, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (16714787..16723533, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in male germline ring canal	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

Names: CG9985-PA; CG9985-PB; CG9985-PC; PIP5-kinase; fata morgana; phosphatidylinositol 4-phosphate 5-kinase; sktl-PA; sktl-PB; sktl-PC; type I phosphatidylinositol 4-phosphate 5-kinase