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    Crag Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31800, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cragprovided by FlyBase
    Official Full Name
    Calmodulin-binding protein related to a Rab3 GDP/GTP exchange proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025864
    Locus tag
    Dmel_CG12737
    See related
    AllianceGenome:FB:FBgn0025864
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12737; CJ; crag; CRAG; Dmel\CG12737
    Summary
    Enables calmodulin binding activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Involved in several processes, including basal protein localization; basolateral protein secretion; and extracellular matrix organization. Located in several cellular components, including apical cortex; lateral cell cortex; and recycling endosome. Is expressed in adult head; follicle cell; germarium; and organism. Orthologous to several human genes including DENND4C (DENN domain containing 4C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Crag in Genome Data Viewer
    Location:
    7F7-7F8; 1-23 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8592031..8602036)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8486064..8496069)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chromatin assembly factor 1, p180 subunit Neighboring gene ocelliless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. uDENN, DENN, and dDENN: indissociable domains in Rab and MAP kinases signaling pathways. Levivier E, et al. Biochem Biophys Res Commun, 2001 Sep 28. PMID 11563850
    2. Dynamic regulation of basement membrane protein levels promotes egg chamber elongation in Drosophila. Isabella AJ, et al. Dev Biol, 2015 Oct 15. PMID 26348027, Free PMC Article
    3. A Drosophila Model for Clostridium difficile Toxin CDT Reveals Interactions with Multiple Effector Pathways. Schwartz R, et al. iScience, 2020 Feb 21. PMID 32058973, Free PMC Article
    4. Stratum, a Homolog of the Human GEF Mss4, Partnered with Rab8, Controls the Basal Restriction of Basement Membrane Proteins in Epithelial Cells. Devergne O, et al. Cell Rep, 2017 Feb 21. PMID 28228250, Free PMC Article
    5. Polarized deposition of basement membrane proteins depends on Phosphatidylinositol synthase and the levels of Phosphatidylinositol 4,5-bisphosphate. Devergne O, et al. Proc Natl Acad Sci U S A, 2014 May 27. PMID 24828534, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in basal protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basement membrane assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basement membrane constituent secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in basolateral protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in positive regulation of Golgi to plasma membrane protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in regulation of Rab protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of Rab protein signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of basement membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lateral cell cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein
    Names
    CG12737-PA
    CG12737-PB
    CG12737-PD
    Calmodulin-binding protein related to a Rab3 GDP-GTP exchange protein
    Crag-PA
    Crag-PB
    Crag-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8592031..8602036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169239.2 → NP_001162710.2  Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162710.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96957, Q8T3K8, Q9W3D2, Q9W3D3
      Conserved Domains (4) summary
      smart00801
      Location:551 → 624
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:189 → 279
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:808 → 837
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308 → 492
      DENN; DENN (AEX-3) domain

    2. NM_080341.4 → NP_525080.3  Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525080.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96957, Q8T3K8, Q9W3D2, Q9W3D3
      Related
      FBpp0071165
      Conserved Domains (4) summary
      smart00801
      Location:551 → 624
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:189 → 279
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:808 → 837
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308 → 492
      DENN; DENN (AEX-3) domain

    3. NM_167164.4 → NP_727281.2  Calmodulin-binding protein related to a Rab3 GDP/GTP exchange protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727281.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3D2
      Related
      FBpp0089320
      Conserved Domains (4) summary
      smart00801
      Location:551 → 624
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:189 → 279
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      sd00004
      Location:808 → 837
      PPR; PPR repeat [structural motif]
      pfam02141
      Location:308 → 492
      DENN; DENN (AEX-3) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3D3.3 Q9W3D3

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